Randomized Trial of Intraoperative IV Versus Preoperative Oral Acetaminophen During Ambulatory Lumbar Discectomy

Launched by ROTHMAN INSTITUTE ORTHOPAEDICS · Sep 29, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating the best way to manage pain for patients undergoing a specific type of spine surgery called ambulatory lumbar discectomy. Researchers want to compare two methods of giving acetaminophen, a common pain reliever: one group will receive it through an IV during the surgery, while the other group will take it by mouth before the surgery begins. The goal is to see which method helps reduce the need for stronger pain medications (opioids), lowers pain levels after surgery, and allows patients to recover and go home sooner.

To participate in this trial, you need to be at least 18 years old, weigh more than 50 kg, and be able to speak English. However, there are some conditions that would prevent you from joining, such as being pregnant, having certain medical issues, or taking high doses of opioids. If you decide to join, you can expect to be closely monitored for pain levels and recovery progress, helping doctors learn the best ways to manage pain after this type of surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age greater than 18 years-old
• • Weight greater than 50 kg body weight
• • ASA physical status I-III
• • English-speaking
• Exclusion Criteria:
• • Weight less than 50 kg
• • Pregnancy or breast feeding
• • revision surgery
• • Contraindications to the administration of acetaminophen (e.g. allergy, liver failure, etc)
• • Chronic pain conditions unrelated to back pain
• • Opioid tolerance ( defined as taking greater than oxycodone 20 mg daily for a week during the past month).