Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia

Launched by GENERAL HOSPITAL OF NINGXIA MEDICAL UNIVERSITY · Sep 30, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how to prevent low blood pressure (hypotension) that can occur after spinal anesthesia in pregnant women with a condition called preeclampsia, who are having a cesarean section (C-section). The researchers want to find out the best dose of a medication called phenylephrine to help keep blood pressure stable during and after the procedure.

To participate, women aged 18 to 45 who are at least 32 weeks pregnant and scheduled for a C-section may be eligible, as long as they don't have certain health issues like very high blood pressure or severe obesity. The trial is not yet recruiting participants, but those who join can expect to receive the medication during their procedure and be monitored for their blood pressure. This study is important because it aims to improve safety and outcomes for mothers with preeclampsia during childbirth.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 18-45 years
• • Primipara or multipara
• • Singleton pregnancy ≥32 weeks
• • American Society of Anesthesiologists physical status classification II to III
• • Scheduled for cesarean section under spinal anesthesia
• Exclusion Criteria:
• • Baseline blood pressure ≥180 mmHg
• • Body height \< 150 cm
• • Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2
• • Eclampsia or chronic hypertension
• • Hemoglobin \< 7g/dl
• • Fetal distress, or known fetal developmental anomaly