Unruptured Cerebral Aneurysm: Prediction of Evolution

Launched by NANTES UNIVERSITY HOSPITAL · Oct 1, 2020

Keywords

ClinConnect Summary

This clinical trial is focused on understanding unruptured intracranial aneurysms (UIAs), which are bulges in blood vessels in the brain that have not yet burst. The researchers aim to gather a large group of patients with these aneurysms to study how they might change over time and to explore potential new ways to evaluate and treat them. This study will involve detailed imaging tests, like MRI scans, and will follow participants for three years to collect important health information.

To be eligible for this trial, participants should be over 18 years old and have a specific type of unruptured aneurysm that measures between 3 and 7 mm. They should not have any serious health issues that would prevent them from undergoing MRI scans or using contrast dyes during imaging. Those who participate can expect regular check-ups and tests to monitor their aneurysm and help researchers learn more about how these conditions develop. It's a chance to contribute to important research that could improve future treatments for others with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria :
• • Subject carrying unruptured, asymptomatic and untreated typical IA of bifurcation, measured on conventional imaging (MRI, CTA or DSA) between 3 and 7 mm of larger diameter.
• • Ability to be followed-up during 3 years decided in consensus multidisciplinary gathering.
• • Age \> 18 years old.
• Exclusion Criteria :
• • A failure to obtain informed consent
• • Contraindications for undergoing an MRI scan include : (heart pacemaker, a metallic foreign body (metal sliver) in their eye, or aneurysm clip in their brain, severe claustrophobia)
• • Contraindications for a gadolinium contrast medium injection (:eGFR below 30 mL/min/1.73 m2, Previous or pre-existing nephrogenic systemic fibrosis, Previous anaphylactic/anaphylactoid reaction to gadolinium containing contrast agent, Acutely deteriorating renal function, Pregnancy and breast-feeding)
• • A mycotic, fusiform-shaped, or dissecting IA, an IA in relation with an arteriovenous malformation
• • A family history of polycystic kidney disease, Ehlers-Danlos syndrome, Marfan's syndrom, fibromuscular dysplasia, or Moya Moya disease
• • Intra-cavernous UIA because the sinus cavernous that is fulfilled with venous blood precluded a reliable assessment of aneurysmal wall enhancement (AWE)