Effects of Visnadin, Ethyl Ximeninate, Coleus Barbatus and Millet in Emulgel on Sexual Function in Postmenopausal Women

Launched by CHULALONGKORN UNIVERSITY · Oct 6, 2020

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of a special cream called emulgel, which contains four natural ingredients: visnadin, ethyl ximeninate, coleus barbatus, and millet. The study focuses on how this cream may help improve sexual function in postmenopausal women who are experiencing symptoms of vulvovaginal atrophy, a condition that can cause discomfort and dryness in the vaginal area. Over an 8-week period, researchers will compare the effects of the cream with the active ingredients to a version of the cream without them. The goal is to see if the cream can make a difference in symptoms and to ensure it is safe and well-tolerated.

To participate in this study, women aged 45 to 65 who have gone through menopause or had their ovaries removed for more than a year may be eligible. They should have moderate to severe symptoms of vulvovaginal atrophy and be sexually active at least once a month. However, women who have used certain hormonal treatments recently or have specific health issues may not qualify. If you decide to join, you can expect regular check-ins at the Menopause and Gynecology Clinics in Bangkok, Thailand, and you’ll be part of important research that aims to improve women's health and well-being.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women age 45-65 years old
• • BMI 19-29 kg/m2
• • Menopause or removal of both ovaries more than 1 year
• • Has moderate to severe vulvovaginal atrophic at least 1 symptom
• • Has sign of vulvovaginal atrophy
• • Vaginal pH ≥ 5
• • Has sexual intercourse at least 1 time/month
• Exclusion Criteria:
• • Hormonal use within 3 months
• • Use vaginal estrogen/ moisturizer within 3 months
• • Use aromatase inhibitor/tamoxifen within 3 months
• • Has vaginal bleeding within 6 months
• • Acute or chronic urinary tract infection
• • History of radiation therapy at vulvovaginal and pelvic area
• • History of Diabetes mellitus or Cardiovascular disease
• • History of neurosis or psychosis
• • History of vulvovaginal cancer
• • History of smoking more than 20 cigarettes/day
• • History of alcoholic drink/ drug abuse
• • History of visnadin, ethyl ximeninate, coleus barbatus and millet allergy
• • Has disease of vulva