Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT)

Launched by CAREGGI HOSPITAL · Oct 7, 2020

Keywords

ClinConnect Summary

The GlobalARRT trial is studying a treatment called Extracorporeal Blood Purification (EBP) for critically ill patients, particularly those suffering from conditions like acute kidney injury and sepsis. This treatment aims to remove harmful substances from the blood that can worsen a patient's condition. The goal of this study is to find out which groups of patients benefit the most from EBP, helping doctors make better treatment decisions in the future.

To be eligible for this trial, patients need to be admitted to an Intensive Care Unit (ICU) and require one of several specific blood purification treatments. These treatments can include methods for kidney support or therapies designed to remove inflammatory substances from the blood. Participants in the study will have their treatment and recovery monitored closely. Importantly, there aren’t strict exclusion criteria, meaning that a wide variety of patients may be included to reflect real-world medical practices. This trial is currently recruiting, so there are opportunities for patients to participate and contribute to important research that could improve future care for critically ill individuals.

Gender

ALL

Eligibility criteria

• Inclusion Criteria: patients who meet all the following inclusion criteria may be included in this study:
• • 1. Admission to ICU
• 2. Indications for at least one of the following extracorporeal blood purification treatments:
• • 1. Continuous Renal Replacement Therapy (CRRT) / Intermittent Hemodialysis (IHD) / Hybrid therapies for renal support/replacement;
• • 2. Immunomodulation therapy in critically ill patients using hemodiafilters with larger pore sizes characterized by enhanced transmembrane clearance of larger molecules (such as cytokines), hemodiafilters with enhanced unselective absorption of cytokines and/or endotoxins, cartridges with enhanced absorption of cytokines and/or endotoxins, techniques aimed at improving extracorporeal removal of cytokines and/or endotoxins.
• • It should be underlined that the lack of established guidelines on the use of membranes for extracorporeal blood purification (and on RRTs in general) leads to variability in clinical practice and treatments are initiated in accordance with the judgement of the responsible physician. Under these circumstances, it is preferable to keep inclusion criteria as wide as possible so as to obtain a real picture of clinical practice worldwide.
• • Exclusion Criteria: besides contraindications to the use of the EBP adopted (as from the manual of instructions), there are no exclusion criteria.