Comparison of Potassium Binders in the ER

Launched by UNIVERSITY OF CALIFORNIA, IRVINE · Oct 6, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of three different oral medications, known as potassium binders, in lowering high levels of potassium in the blood, a condition called acute hyperkalemia. High potassium levels can be dangerous and are often treated in hospitals. The trial is currently recruiting participants who are at least 18 years old and have a blood potassium level higher than 5.5 mEq/L. To take part, patients must be able to give their consent and should not have certain health issues, such as recent bowel surgery or pregnancy.

Participants in this trial can expect to receive one of the three medications and will be monitored to see how well it works in reducing their potassium levels. This study is important because it aims to find out which of these medications is the most effective, helping doctors choose the best treatment for patients with high potassium levels in the future. If you're considering joining the trial, it's essential to discuss it with your healthcare provider to ensure it's a good fit for your health needs.

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Eligibility criteria

• Inclusion Criteria:
• • Plasma potassium \> 5.5 mEq/L
• • Age ≥18 years
• • Patient able to provide written informed consent
• Exclusion Criteria:
• • Recent bowel surgery
• • Ileus or bowel obstruction
• • Pseudohyperkalemia signs and symptoms, such as excessive fist clenching, hemolyzed blood specimen, severe leukocytosis or thrombocytosis
• • Pregnancy
• • Active psychiatric disorder
• • Diabetic ketoacidosis or hyperkalemia caused by any condition for which a therapy directed against the underlying cause of hyperkalemia would be a better treatment option
• • Dialysis session expected within 4 hours after randomization
• • History of hypersensitivity to sodium polystyrene sulfonate resin or patiromer
• • Concurrent use of sorbitol (due to increased risk of intestinal necrosis when used with sodium polystyrene sulfonate)