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Search / Trial NCT04585698

QST, Blink Reflex and Nociceptive Flexion Reflex in Headache

Launched by UNIVERSITY OF LIEGE · Oct 12, 2020

Trial Information

Current as of August 02, 2025

Unknown status

Keywords

Headache Fremanezumab Blink Reflex Nociceptive Flexion Reflex Quantitative Sensory Testing

ClinConnect Summary

20 patients and 20 healthy subjects will be enrolled. The headache patients will be recruited just before starting their treatment and 1 month after (corresponding to the efficacy peak). Hot and cold stimulations will be delivered with the ATS probe from the Medoc Pathway on the forehead and on the hand (palmar face) to determine painful threshold to warm/cold stimuli. A blink reflex will be generated with a concentric electrode placed over the eyebrow and with active/earth electrodes linked to the EMG machine for the recording. For the nociceptive flexion reflex, a cutaneous stimulation wi...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria: patients with headache which are about to receive a treatment with fremanezumab
  • Exclusion Criteria:
  • medication changes 1 month prior to the test
  • neuropathy
  • acute or chronic pain
  • medications having effects on the central nervous system
  • other disease

About University Of Liege

The University of Liège, a prestigious research institution in Belgium, is committed to advancing medical science through innovative clinical trials. With a focus on interdisciplinary collaboration, the university leverages its extensive expertise in various fields, including medicine, pharmacology, and biomedical engineering, to conduct high-quality research aimed at improving patient outcomes. The institution fosters a rigorous ethical framework and adheres to international standards in clinical research, ensuring the integrity and reliability of its studies. Through its clinical trials, the University of Liège aims to contribute significantly to the development of novel therapeutic approaches and enhance the understanding of complex health issues.

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Patients applied

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Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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