ABC - A Post Intensive Care Anaemia Management Trial

Launched by UNIVERSITY OF EDINBURGH · Oct 16, 2020

Keywords

ClinConnect Summary

The ABC Post Intensive Care Anaemia Management Trial is studying how to help patients who have become anemic after spending time in the intensive care unit (ICU). Anemia means having low levels of hemoglobin, which can make you feel very tired and weak. This trial will look at whether giving red blood cell (RBC) transfusions, which are blood products that can help increase hemoglobin levels, improves the health and quality of life for these patients after they leave the ICU. Specifically, it will compare the usual approach of giving fewer transfusions to a more active approach where transfusions are given more readily to correct anemia.

To participate in the trial, patients must be 16 years or older, have received intensive care, and have a hemoglobin level of 94g/L or lower when they are ready to leave the ICU. They must also be expected to stay in the hospital until they are fully discharged. Throughout the trial, patients will have their hemoglobin levels checked regularly and receive transfusions as needed based on their assigned treatment group. Participants will also complete questionnaires about their quality of life at certain points during the study and for up to six months afterward. This is an important trial to find out how best to support recovery for ICU patients dealing with anemia.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient who received level 3 ICU care at any time point during the current hospital admission (defined as advance respiratory support and/or at least two organ support).
• • Patient considered ready for discharge from ICU by the caring clinical team.
• • Hb less than or equal to 94g/L when ready for ICU discharge or during the first seven days following the decision by the treating clinician that the patient is ready for ICU discharge.
• • 16years of age or older
• • Patient expected to remain in study hospital until hospital discharge.
• • Consent provided (by participant or in accordance with appropriate mental capacity legislation for the site).
• Exclusion Criteria:
• • Contraindication or objection to RBC transfusion
• • Active bleeding when screened
• • Primary neurological ICU admission diagnosis
• • Patients discharged from the ICU following cardiac surgery
• • Currently receiving or planned to receive end-of-life care
• • Not expected by clinical team to survive to hospital discharge
• • Patient with a proven chronic haematological disease that requires regular RBC transfusion to treat anaemia
• • Patient with dialysis-dependent chronic renal failure prior to ICU admission
• • Patient receiving regular erythropoietin (or any erythropoiesis stimulating agent) treatment for anaemia prior to ICU admission
• • Unable to obtain consent (frompatietn or in accordance with appropriate mental capacity legislation for the site)
• • Readmission to ICU during current hospitalisation episode and not enrolled following previous ICU admissions