High Definition Transcranial Direct Current Stimulation (HD-tDCS) for Early Alzheimer's Disease

Launched by ANHUI MEDICAL UNIVERSITY · Oct 18, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called high-definition transcranial direct current stimulation (HD-tDCS) combined with cognitive training for people with early Alzheimer's disease. The goal is to understand how this treatment may help improve brain function and cognitive abilities in those affected by early stages of Alzheimer’s. Researchers are currently looking for participants aged 18 to 85 who have been diagnosed with early Alzheimer's disease and have mild cognitive impairment.

To be eligible to participate, individuals must have a certain level of cognitive function, as indicated by specific tests, and have been receiving certain medications for at least three months. Participants can expect to receive the HD-tDCS treatment along with cognitive training exercises, and their brain activity will be monitored throughout the study. It's important to know that individuals with a history of severe psychiatric conditions, certain neurological diseases, or specific medical devices may not qualify for this trial. This research could provide valuable insights into new ways to support people with early Alzheimer’s and improve their daily lives.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subject diagnosed with early Alzheimer's disease or related diseases according to NINCDS-ACDRADA criteria.
• • Subjects must have a MMSE score between 10 and 27,indicating mild cognitive impairment or dementia
• • CDR score ≤ 2
• • Subject under treatment by IAChE for at least 3 months.
• • psychotropic treatments are tolerated if they were administered and unchanged for at least 3 months
• Exclusion Criteria:
• • CDR \> 2
• • Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder).
• • History of head injury,stroke,or other neurologic disease.
• • Organic brain defects on T1 or T2 images.
• • History of seizures or unexplained loss of consciousness.
• • Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator.
• • Family history of medication refractory epilepsy.
• • History of substance abuse within the last 6 months.