Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI

Launched by SAM TYAGI · Oct 19, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the effects of low-dose ketamine on patients who are having a special type of surgery called thoracic endovascular aortic repair (TEVAR). The goal is to see if ketamine can help reduce pain and lessen the need for stronger pain medications, like opioids, for patients who are also receiving a medication called naloxone to protect against certain side effects during recovery.

To participate in this trial, you need to be between the ages of 18 and 75, be scheduled for elective thoracic aorta or thoracoabdominal repair surgery, and require naloxone for spinal pain management. You'll need to be able to give your consent to participate. However, if you have allergies to ketamine or other specific medications, or if you have certain medical conditions, you may not be eligible. If you join the study, you can expect to receive either ketamine or a placebo (a non-active treatment) during your surgery to help manage your pain. This research could help improve pain management for future patients undergoing similar procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • willing to give informed consent
• • scheduled for elective thoracic aorta repair or thoracoabdominal aortic repair
• • requires naloxone continuous infusion for spinal prophylaxis
• Exclusion Criteria:
• • allergy to ketamine, acetaminophen, or fentanyl
• • diagnosis of schizophrenia
• • history of hydrocephalus or central nervous system mass
• • incarcerated individuals
• • pregnant or lactating individuals