Rare Obesity Cohorts With Food Behavioral Disorders : Better Diagnosis for Better Treatment

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Oct 21, 2020

Keywords

ClinConnect Summary

The clinical trial titled "Rare Obesity Cohorts With Food Behavioral Disorders: Better Diagnosis for Better Treatment" is focused on understanding a specific type of obesity called hypothalamic obesity (HO). This condition arises from changes or damage to the hypothalamus, a part of the brain that helps control hunger and energy balance. HO can cause severe obesity along with eating disorders and other health issues, significantly affecting quality of life. The goal of the trial is to improve how we diagnose HO and to explore new treatment options, particularly innovative medications that target the brain's hunger signals.

To participate in this study, individuals must be at least 18 years old with a body mass index (BMI) over 35, or children under 18 with severe obesity or eating behavior disorders. Participants will undergo evaluations to better understand their eating habits and overall health, which can lead to personalized care plans. It's also important that participants can communicate in French and understand the study's purpose. By joining this trial, participants will contribute to identifying better treatments for this challenging and rare form of obesity.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Population 1:
• • 1. Adults ≥ 18 years old with BMI\> 35 kg / m² or children \<18 years old with BMI Zscore\> + 3DS for age and sex and / or eating behavior disorders consulting in one of the participating centers
• 2. Patient benefiting from a genetic diagnosis as part of his usual care according to criteria justifying a genetic analysis such as:
• • obesity with early onset (\<12 years) or very severe BMI\> 50 kg / m² and / or presence of eating disorders, endocrine abnormalities or other symptoms suggestive of a genetic anomaly (such as: intellectual disability, retinopathy of pigmentation or other)
• • 3. Adult patient or holders of parental authority (for children) having received the information and having signed a free, informed and written consent (or for adult patients under legal protection measure or unable to consent, information and obtaining the consent of the legal representative, the support person, or the relative / close relative).
• • Population 2
• • 1. Adult or child with obesity and / or eating disorder due to hypothalamic lesion (craniopharyngioma for example)
• • 2. Adult patient or holders of parental authority (for children) having received the information and having signed a free, informed and written consent (or for adult patients under legal protection measure or unable to consent, information and obtaining the consent of the legal representative, the support person, the relative / relative).
• Exclusion Criteria:
• • 1. Refusing to participate in the study
• • 2. Not mastering the french language
• • 3. Safety measure