HFNO or Conventional Oxygen Therapy for Patients With Acute Hypoxemic Respiratory Distress

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE BESANCON · Oct 28, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of High Flow Nasal Oxygen (HFNO) compared to conventional oxygen therapy for patients suffering from acute respiratory distress, a serious condition where the lungs can't get enough oxygen into the blood. The researchers want to find out if using HFNO early can help these patients breathe better and possibly reduce the need for more invasive treatments like ventilators. HFNO delivers a higher flow of oxygen, which can make patients more comfortable and improve their oxygen levels.

To participate in the trial, you need to be over 18 years old and have been admitted to the Emergency Department with severe breathing difficulties, which is indicated by a rapid breathing rate and low oxygen levels in your blood. However, if you have certain conditions like high carbon dioxide levels in your blood, or if you need specific types of ventilation support, you may not be eligible. Participants in the trial will receive either HFNO or traditional oxygen treatment and will be closely monitored to see which method helps them recover better. This study aims to provide more evidence on the best ways to treat patients with severe breathing issues in emergency situations.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients over 18 years of age
• * Admitted to the Emergency Department for acute respiratory distress :
• • Respiratory rate ≥ at 25 cycles/min.
• • And SpO2 ≤ at 95% without or with oxygen whatever the mode.
• • And clinical signs of respiratory distress (pulling, thoraco-abdominal swinging).
• • And PaO2/FIO2 ratio \< 300mmHg.
• Exclusion Criteria:
• • Hypercapnic patients (PaCO2 \> 45mmHg) with respiratory acidosis (pH\<7.30).
• • Indication for non-invasive ventilation or early invasive mechanical ventilation according to current scientific recommendations (acute pulmonary edema, Chronic obstructive pulmonary disease decompensation, or others).
• • Dyspnea of traumatic origin.
• • Traumatic pneumothorax.
• • Hemodynamic instability (PAM\<65mmHg).
• • Patients treated with Mobile Emergency and Resuscitation Service (SMUR) who have already received cardiac or pulmonary treatment.
• • Patients with cognitive deterioration (Glasgow score less than 13, dementia or mental failure that would prevent good cooperation).
• • Patients with lesion(s) of the oro-nasal sphere contraindicated for the implementation of High Flow Nasal Oxygen Therapy.
• • Subject unlikely to cooperate in the study and/or low cooperation anticipated by the investigator.
• • Subject without health insurance.
• • Pregnant woman.
• • Subject being in the exclusion period of another study or included in the "national volunteer file".