Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression

Launched by CAIRO UNIVERSITY · Oct 25, 2020

Keywords

ClinConnect Summary

After confirming the diagnosis and making sure that the patient conforms to all eligibility criteria, the principal investigator will enroll the patient in the study.

* Patients will be asked to rate their pre-operative pain intensity (ie, before the commencement of any treatment \[baseline score\]; on the visual analogue scale "VAS"
* Enrolled patients will be randomly assigned into one of three groups:

Intervention Group 1 (Diclofenac Potassium): single, oral dose of 50 mg diclofenac potassium pre-medication (Cataflam; NOVARTIS Pharma, Basel, Switzerland) one hour before starting endodo...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 18-50 years.
• • Males and females.
• • American Society of Anesthesiologists class 1 or 2.
• * Mandibular premolar teeth with:
• • Endodontic pulpal diagnosis of symptomatic irreversible pulpitis
• • Normal/slight widening in the periodontal membrane space (PMS).
• • Patients who had not taken any anti-inflammatory drugs the day of the root canal procedure unless they belong to one of the intervention groups.
• • Patients who accept to participate in the trial, understand the VAS, and can sign the informed consent
• Exclusion Criteria:
• • Cases with acute peri-apical conditions (acute apical periodontitis/ acute apical abscess), pulpal necrosis, previously initiated therapy, or previously treated.
• • Teeth other than single-rooted teeth.
• • Radiographic evidence of external or internal root resorption vertical root fracture, perforation, or calcification.
• • Immature teeth.
• • Unrestorable teeth or teeth with severe periodontal disease.
• • Patients with a known allergy, sensitivity, or history of other adverse reactions to the medications administered.
• • Patients with a history of active peptic ulcer within the preceding 12 months, bleeding problems, anticoagulant use within the last month, or kidney disease.
• • Patients who took analgesics/ anti-inflammatory drugs (steroidal or non-steroidal) the day of endodontic treatment.
• • Pregnant or nursing females.
• • Patients who are unable to provide informed consent