Bleeding in Laparoscopic Liver Surgery

Launched by UNIVERSITÀ VITA-SALUTE SAN RAFFAELE · Oct 25, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a specific type of anesthesia called deep neuromuscular blockade on blood loss during laparoscopic liver surgery, which is a minimally invasive way to remove part of the liver. Researchers want to find out if using deeper levels of neuromuscular blockade can help reduce bleeding during the surgery. Patients who are 18 years or older and are scheduled for laparoscopic liver resection may be eligible to participate in this study. However, those with certain medical conditions, such as very low platelet counts or active bleeding, will not be included.

If you decide to take part in this trial, you will be randomly assigned to receive either deep neuromuscular blockade or a moderate level during your surgery. Throughout the procedure, the medical team will monitor your neuromuscular blockade to ensure it's at the right level. The main goal is to measure the total amount of blood loss at the end of the surgery. This study aims to improve surgical outcomes and reduce complications for patients undergoing liver surgery, so your participation could help advance medical knowledge in this area.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing laparoscopic liver resection
• • Patients ≥ 18 years old
• • Patients willing to participate to the study and able to validly sign informed consent.
• Exclusion Criteria:
• • Patients presenting a pre-operative platelet count \< 50 x 109/L and/or patients with active pre-operative bleeding
• • Patients with planned requirement of continuous neuromuscular blockade monitoring (upon clinical judgement)
• • Known hypersensitivity / previous allergic reactions to study medications
• • Planned total intra-venous anesthesia technique
• • Pregnant or breastfeeding patients.