MICRO: a Registry Study in Patients With Microvascular Angina

Launched by JOHANNES GUTENBERG UNIVERSITY MAINZ · Oct 27, 2020

Keywords

ClinConnect Summary

The MICRO study is a clinical trial designed to learn more about microvascular angina, a condition that affects small blood vessels in the heart and can cause chest pain and discomfort. The trial aims to better understand how this condition impacts patients and to identify factors that may influence their health outcomes. This research is important because many people with microvascular disease suffer from significant symptoms, but there is still confusion about how to properly diagnose and manage it.

To participate in this study, individuals need to be between 18 and 84 years old and have a history of chronic coronary syndrome, which includes symptoms like angina (chest pain). They should also have evidence of heart issues from specific tests. Participants will be asked to undergo certain heart measurements and will need to sign a consent form to confirm they understand the study. This research is currently recruiting participants, and it offers a chance to contribute to important findings that could improve care for others with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 and \<85 years.
• • Chronic coronary syndrome (including patients with anginal equivalents)
• • Angina CCS class II-IV
• • Evidence of reversible ischemia on non-invasive testing
• * Availability of the following measurements:
• • 1. Index of microvascular resistances (IMR),
• • 2. Resting full-cycle ratio (RFR),
• • 3. Fractional flow reserve (FFR),
• • 4. Coronary flow reserve (CFR)
• • Willingness to participate and ability to understand read and signed the informed consent document before the procedure
• Exclusion Criteria:
• At least one of the following:
• • Pregnancy and or lactation.
• • Medical or psychological conditions that would jeopardize an adequate and orderly participation.
• • Left ventricular ejection fraction lower than 30%
• • Previous coronary artery bypass surgery (CABG) to all major branches in the LAD and left circumflex (LCX) territory, such that IMR cannot be measured
• • Decompensated congestive heart failure (CHF)
• • Chronic or acute renal failure with creatinine \>2mg/dl
• • Severe valvular heart disease
• • Patients with comorbidities limiting life expectancy to less than one year