Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Launched by MIRATI THERAPEUTICS INC. · Oct 30, 2020
Trial Information
Current as of September 30, 2025
Recruiting
Keywords
ClinConnect Summary
The KRYSTAL-7 trial is studying a new treatment for patients with advanced non-small cell lung cancer (NSCLC) that has a specific mutation called KRAS G12C. The trial has two parts: the Phase 2 part is looking at how well the drug adagrasib works alone or when combined with another medication called pembrolizumab. This part is for patients who have not received prior treatment and have any level of a protein called PD-L1. The Phase 3 part will compare the effects of adagrasib combined with pembrolizumab against pembrolizumab alone in patients with similar cancer characteristics but with a higher level of PD-L1.
To be eligible for this trial, participants must have a confirmed diagnosis of advanced or metastatic NSCLC with the KRAS G12C mutation. They should not have received prior systemic treatments for their cancer, and specific criteria regarding brain health must be met. Participants can expect close monitoring from the research team throughout the study, and their health will be evaluated regularly to determine how well the treatment is working. This trial is currently recruiting patients, and it aims to find effective treatment options for those facing this challenging condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Phase 2: Histologically confirmed diagnosis of unresectable or metastatic NSCLC with KRAS G12C mutation and any PD-L1 TPS
- • Phase 3: Histologically confirmed diagnosis of unresectable or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS \>=50%
- • Phase 3: Presence of evaluable or measurable disease per RECIST
- * Phase 3: CNS Inclusion - Based on screening brain imaging, patients must have one of the following:
- • 1. No evidence of brain metastases
- • 2. Untreated brain metastases not needing immediate local therapy
- • 3. Previously treated brain metastases not needing immediate local therapy
- Exclusion Criteria:
- • Phase 2 and Phase 3: Prior systemic treatment for locally advanced or metastatic NSCLC including chemotherapy, immune checkpoint inhibitor therapy, or a therapy targeting KRAS G12C mutation (e.g., AMG 510).
- • Phase 2: Active brain metastases
- * Phase 3: Patients with known central nervous system (CNS) lesions must not have any of the following:
- • 1. Any untreated brain lesions \> 1.0 cm in size
- • 2. Any brainstem lesions
- • 3. Ongoing use of systemic corticosteroids for control of symptoms of brain lesions at a total daily dose of \> 10 mg of prednisone (or equivalent) prior to randomization.
- • 4. Have poorly controlled (\> 1/week) generalized or complex partial seizures, or manifest neurologic progression due to brain lesions notwithstanding CNS-directed therapy
- • Phase 3: Radiation to the lung \> 30 Gy within 6 months prior to the first dose of study treatment
About Mirati Therapeutics Inc.
Mirati Therapeutics, Inc. is a biopharmaceutical company dedicated to discovering and developing transformative therapies for patients with genetically defined cancers. With a strong focus on precision medicine, Mirati leverages advanced science and innovative technologies to identify and target specific genetic mutations driving cancer progression. The company’s robust pipeline includes novel small molecules and immunotherapies, aimed at addressing significant unmet medical needs and improving patient outcomes. Committed to advancing oncology research, Mirati collaborates with healthcare professionals and research institutions to bring cutting-edge treatments from the lab to the clinic.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Tbilisi, Georgia
Monchengladbach, Germany
Istanbul, Turkey
Izmir, Turkey
Fort Myers, Florida, United States
Esslingen, Baden Wuerttemberg, Germany
Long Beach, California, United States
Whittier, California, United States
Miami, Florida, United States
Orlando, Florida, United States
Vratsa, Bulgaria
London, Ontario, Canada
Giessen, Germany
Krakow, Poland
Taichung, Taiwan
Gabrovo, Bulgaria
Chai Wan, Hong Kong
Dublin, Ireland
Plovdiv, Bulgaria
Chicago, Illinois, United States
Nashville, Tennessee, United States
Lexington, Kentucky, United States
Lisbon, Portugal
Porto, Portugal
Prescott Valley, Arizona, United States
Cerritos, California, United States
Los Alamitos, California, United States
Los Angeles, California, United States
Rancho Mirage, California, United States
San Francisco, California, United States
Jacksonville, Florida, United States
Westwood, Kansas, United States
Wichita, Kansas, United States
Baltimore, Maryland, United States
Durham, North Carolina, United States
Belleville, New Jersey, United States
Teaneck, New Jersey, United States
Cleveland, Ohio, United States
Kettering, Ohio, United States
Allentown, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Nashville, Tennessee, United States
Austin, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Fairfax, Virginia, United States
Vancouver, Washington, United States
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Bedford Park, Australia
Clayton, Australia
Monteria, Colombia
Linz, Austria
Ostrava, Czechia
Edegem, Belgium
Porto Alegre, Rio Grande Do Sul, Brazil
West Palm Beach, Florida, United States
Garran, Australia
Heidelberg, Germany
Long Beach, California, United States
Germantown, Tennessee, United States
Tigard, Oregon, United States
Denison, Texas, United States
Buenos Aires, Argentina
Woolloongabba, Australia
Amarillo, Texas, United States
Wien, Austria
Kunming, Yunnan, China
Beijing, Beijing, China
Tampere, Finland
Kowloon, Hong Kong
Belagavi, India
Chongqing, Chongqing, China
Busan, Korea, Republic Of
Jaipur, India
Kolkata, India
Suwon Si, Korea, Republic Of
Madurai, India
Coimbra, Portugal
Sankt Gallen, Switzerland
London, United Kingdom
Edmonton, Alberta, Canada
Burnsville, Minnesota, United States
Barcelona, Spain
Jackson, Mississippi, United States
Honolulu, Hawaii, United States
Edirne, Turkey
Praha 2, Czechia
Molo, Philippines
La Tronche, France
Pretoria, Gauteng, South Africa
Rajkot, India
Madison, Wisconsin, United States
Albany, New York, United States
Dallas, Texas, United States
Wollongong, Australia
Honolulu, Hawaii, United States
Sao Jose Do Rio Preto, Brazil
Tyler, Texas, United States
Sioux Falls, South Dakota, United States
Incheon, Gyeonggi Do, Korea, Republic Of
Sofia, Bulgaria
Pensacola, Florida, United States
London, England, United Kingdom
Athens, Georgia, United States
West Palm Beach, Florida, United States
Lone Tree, Colorado, United States
Omaha, Nebraska, United States
Fredericksburg, Texas, United States
Anaheim, California, United States
Safford, Arizona, United States
Salem, Oregon, United States
Fredericksburg, Texas, United States
Sarasota, Florida, United States
Denver, Colorado, United States
Kingman, Kansas, United States
Abilene, Texas, United States
Hasselt, Belgium
Beijing, Beijing, China
Laguna Hills, California, United States
Long Beach, California, United States
Santa Ana, California, United States
Colorado Springs, Colorado, United States
Centennial, Colorado, United States
East Brunswick, New Jersey, United States
Colorado Springs, Colorado, United States
Arlington Heights, Illinois, United States
Naples, Florida, United States
Chanute, Kansas, United States
Newton, Kansas, United States
Parsons, Kansas, United States
Louisville, Kentucky, United States
Covington, Louisiana, United States
Omaha, Nebraska, United States
Papillion, Nebraska, United States
Covington, Louisiana, United States
Somerset, New Jersey, United States
Somerset, New Jersey, United States
Somerset, New Jersey, United States
Cincinnati, Ohio, United States
Hendersonville, Tennessee, United States
Hermitage, Tennessee, United States
Arlington, Texas, United States
Austin, Texas, United States
Irving, Texas, United States
Longview, Texas, United States
Nashville, Tennessee, United States
Nashville, Tennessee, United States
Shelbyville, Tennessee, United States
Saint Augustine, Florida, United States
Roma, Italy
Stuart, Florida, United States
Pratt, Kansas, United States
Tbilisi, Georgia
Edina, Minnesota, United States
Austin, Texas, United States
Bonita Springs, Florida, United States
Immenstadt, Bayern, Germany
Jacksonville, Florida, United States
Naples, Florida, United States
Salina, Kansas, United States
Wellington, Kansas, United States
Tigard, Oregon, United States
Lisboa, Portugal
Las Vegas, Nevada, United States
Bedford, Texas, United States
Port Charlotte, Florida, United States
Whittier, California, United States
Carrollton, Georgia, United States
Makati City, Philippines
Littleton, Colorado, United States
The Woodlands, Texas, United States
Lebanon, Tennessee, United States
Pueblo, Colorado, United States
Bradenton, Florida, United States
Fleming Island, Florida, United States
Safford, Arizona, United States
Murfreesboro, Tennessee, United States
Safford, Arizona, United States
Safford, Arizona, United States
Fountain Valley, California, United States
Cape Coral, Florida, United States
Celebration, Florida, United States
Boulder, Colorado, United States
Lakewood, Colorado, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Fort Myers, Florida, United States
Fort Myers, Florida, United States
Venice, Florida, United States
Venice, Florida, United States
Vero Beach, Florida, United States
Wellington, Florida, United States
Hiram, Georgia, United States
Liberal, Kansas, United States
Wichita, Kansas, United States
Cartersville, Georgia, United States
Douglasville, Georgia, United States
Winfield, Kansas, United States
Grand Island, Nebraska, United States
Portland, Oregon, United States
Omaha, Nebraska, United States
Somerset, New Jersey, United States
Cincinnati, Ohio, United States
Dickson, Tennessee, United States
Franklin, Tennessee, United States
Gallatin, Tennessee, United States
Nashville, Tennessee, United States
Nashville, Tennessee, United States
Portland, Oregon, United States
Amarillo, Texas, United States
Arlington, Texas, United States
El Paso, Texas, United States
Alexandria, Virginia, United States
Leesburg, Virginia, United States
Pamplona, Navarre, Spain
Arlington, Virginia, United States
Gainesville, Virginia, United States
Thornton, Colorado, United States
Daytona Beach, Florida, United States
El Paso, Texas, United States
Austin, Texas, United States
Bedford, Texas, United States
Omaha, Nebraska, United States
Independence, Kansas, United States
Las Vegas, Nevada, United States
Midland, Texas, United States
Goodyear, Arizona, United States
Jacksonville, Florida, United States
Varese, Italy
Santiago De Compostela, Spain
Wichita Falls, Texas, United States
Smyrna, Tennessee, United States
Toruń, Poland
A Coruña, Spain
Timisoara, Romania
El Paso, Texas, United States
Las Vegas, Nevada, United States
Napoli, Italy
Parma, Italy
Roma, Italy
Valencia, Spain
Manchester, England, United Kingdom
Otwock, Poland
Skorzewo, Poland
Sevilla, Spain
Roma, Italy
Valencia, Spain
Vienna, Austria
Suwon Si, Korea, Republic Of
Tyler, Texas, United States
San Francisco, California, United States
Jacksonville, Florida, United States
Milan, Italy
Suwon Si, Gyeonggi Do, Korea, Republic Of
Busan, Korea, Republic Of
Anaheim, California, United States
Norwich, Connecticut, United States
Santa Rosa, California, United States
Miami, Florida, United States
Jacksonville, Florida, United States
Atlanta, Georgia, United States
Marietta, Georgia, United States
Peoria, Illinois, United States
Rochester, Minnesota, United States
Jackson, Mississippi, United States
Cincinnati, Ohio, United States
Louisville, Kentucky, United States
Baton Rouge, Louisiana, United States
Spartanburg, South Carolina, United States
Salt Lake City, Utah, United States
Huntington, West Virginia, United States
Madison, Wisconsin, United States
Ballarat, Australia
Klagenfurt Am Woerthersee, Austria
Hasselt, Belgium
Roeselare, Belgium
Gabrovo, Bulgaria
Haskovo, Bulgaria
Salem, Oregon, United States
Plovdiv, Bulgaria
Temuco, Chile
Medellin, Colombia
Tbilisi, Georgia
Esslingen, Germany
Frankfurt Am Main, Germany
Ottawa, Ontario, Canada
Toronto, Ontario, Canada
Grohansdorf, Germany
Jena, Germany
Tatabanya, Hungary
Holon, Israel
Jerusalem, Israel
Bari, Italy
Milano, Italy
Giessen, Germany
Cheongju Si, Korea, Republic Of
Seoul, Korea, Republic Of
Padova, Italy
Dordrecht, Netherlands
Perugia, Italy
Arequipa, Peru
Kielce, Poland
Harderwijk, Netherlands
Warszawa, Poland
Lisbon, Portugal
Otwock, Poland
Timișoara, Romania
Barcelona, Spain
Leon, Spain
Antalya, Turkey
Sevilla, Spain
Bahcelievler, Turkey
Birmingham, United Kingdom
London, United Kingdom
Edinburgh, United Kingdom
Stockton, California, United States
Tucson, Arizona, United States
Washington, District Of Columbia, United States
Tallahassee, Florida, United States
Tampa, Florida, United States
Jacksonville, Florida, United States
Weston, Florida, United States
Bronx, New York, United States
Rhinebeck, New York, United States
Columbus, Ohio, United States
Las Vegas, Nevada, United States
Houston, Texas, United States
Richmond, Virginia, United States
Providence, Rhode Island, United States
Lajeado, Rio Grande Do Sul, Brazil
Vratsa, Bulgaria
Edmonton, Alberta, Canada
Porto Alegre, Argentina
Mulhouse, France
Praha 8 Liben, Czechia
Paris Cedex 05, France
Brest, France
Cork, Ireland
Chemnitz, Germany
Kempten, Germany
Dublin, Ireland
Dublin, Ireland
Rehovot, Israel
Lubeck, Germany
Tel Aviv, Israel
Monza, Italy
Bologna, Italy
Mexico, Distrito Federal, Mexico
Ravenna, Italy
Nijmegen, Netherlands
Trujillo, La Libertad, Peru
Cercado De Lima, Lima, Peru
Barcelona, Spain
Skorzewo, Poland
Malaga, Spain
Torun, Poland
Lisbon, Portugal
Valencia, Spain
Taoyuan, Taiwan
Bornova, Turkey
Taichung City, Taiwan
Cankaya, Turkey
Tainan City, Taiwan
Edirne, Turkey
London, United Kingdom
Istanbul, Turkey
Orlando, Florida, United States
Pensacola, Florida, United States
Jung Gu, Korea, Republic Of
Singapore, Singapore
Utrecht, Netherlands
Valencia, Spain
Bilbao, Spain
Creteil, France
Sisli, Turkey
Safford, Arizona, United States
Burgos, Spain
El Dorado, Kansas, United States
Hořovice, Central Bohemian, Czechia
Beer Sheva, Israel
Denver, Colorado, United States
Klagenfurt, Carinthia, Austria
Genova, Italy
A Coruna, Spain
Málaga, Spain
Stockton, California, United States
Taipei City, Taiwan
Meldola, Italy
Fort Myers, Florida, United States
Leicester, United Kingdom
Chicago, Illinois, United States
Burnsville, Minnesota, United States
Park Ridge, Illinois, United States
Lexington, Kentucky, United States
Eugene, Oregon, United States
Minneapolis, Minnesota, United States
Minneapolis, Minnesota, United States
Ijui, Brazil
Rio De Janeiro, Brazil
Sao Paolo, Brazil
Odessa, Texas, United States
The Woodlands, Texas, United States
Olomouc, Czechia
Rio Cuarto, Argentina
Saint Herblain, France
Villejuif, France
Batumi, Georgia
Afula, Israel
Strasbourg Cedex, France
Tours Cedex 9, France
Meldola, Italy
Aviano, Italy
Firenze, Italy
Seoul, Korea, Republic Of
Monterrey, Mexico
Miraflores, Lima, Peru
Napoli, Italy
Seoul, Korea, Republic Of
San Isidro, Lima, Peru
Vila Nova De Gaia, Portugal
Cluj Napoca, Romania
Surquillo, Lima, Peru
Santander, Spain
Gdansk, Poland
Santiago De Compostela, Spain
Ankara, Turkey
Izmir, Turkey
Jerusalem, Israel
Warszawa, Poland
Gyongyos, Hungary
Limerick, Ireland
Taichung, Taiwan
Madrid, Spain
Barcelona, Spain
Waterford, Ireland
Tainan, Taiwan
Kent, United Kingdom
San Francisco, California, United States
Las Palmas De Gran Canaria, Spain
Athens, Georgia, United States
Niles, Illinois, United States
Boston, Massachusetts, United States
Gent, Belgium
Altindag, Turkey
Farkasgyepu, Hungary
Santiago, Chile
Horovice, Czechia
Torokbalint, Hungary
Milan, Italy
Galway, Ireland
Madrid, Spain
Busan, Korea, Republic Of
Lublin, Poland
Zwolle, Netherlands
A Coruña, La Coruña, Spain
Porto, Portugal
Barcelona, Spain
Taoyuan, Taiwan
Teaneck, New Jersey, United States
Haskovo, Bulgaria
Chicago, Illinois, United States
Milford, Massachusetts, United States
Koln, Germany
Osaka, Japan
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
San Isidro, Lima, Peru
Odense, Denmark
Haskovo, Bulgaria
Pula, Croatia
Hong Kong, Hong Kong
Seoul, Korea, Republic Of
Soenderborg, Denmark
Johannesburg, Gauteng, South Africa
Oslo, Norway
Taipei City, Taiwan
Port Elizabeth, Eastern Cape, South Africa
Roma, Italy
Kassel, Hessen, Germany
San Francisco, California, United States
Villars Sur Glane, Switzerland
Bedford Park, Australia
Kempten, Bavaria, Germany
Amsterdam, Noord Holland, Netherlands
Tainan City, Taiwan
Maywood, Illinois, United States
Charleston, South Carolina, United States
Vienna, Austria
Xiamen, Fujian, China
Seoul, Korea, Republic Of
Budapest, Hungary
Nagasaki Shi, Nagasaki, Japan
Budapest, Hungary
Kanazawa, Japan
Budapest, Hungary
Nankoku Shi, Japan
Ahmedabad, India
Monterrey, Mexico
Baltimore, Maryland, United States
Rotterdam, Netherlands
Jesus Maria, Lima, Peru
Sremska Kamenica, Serbia
Wollongong, New South Wales, Australia
Los Alamitos, California, United States
Niles, Illinois, United States
Ottawa, Ontario, Canada
Bronx, New York, United States
Goshen, Indiana, United States
Cincinnati, Ohio, United States
Covington, Louisiana, United States
Kettering, Ohio, United States
Fairfax, Virginia, United States
Richmond, Indiana, United States
Dallas, Texas, United States
Woolloongabba, Queensland, Australia
Denison, Texas, United States
Lübeck, Schleswig Holstein, Germany
Hemer, Germany
Goyang Si, Korea, Republic Of
Rotterdam, Zuid Holland, Netherlands
Gyöngyös, Hungary
Harderwijk, Netherlands
Lublin, Poland
Odessa, Texas, United States
Afula, Israel
Garran, Australia
Sagamihara, Kanagawa, Japan
Haifa, Israel
Eugene, Oregon, United States
Santa Rosa, California, United States
Oldenburg, Germany
Dublin, Ireland
Reẖovot, Israel
Meldola, Forli Cesena, Italy
Daegu, Korea, Republic Of
L'hospitalet De Llobregat, Barcelona, Spain
Torokbalint, Hungary
Austin, Texas, United States
Rijeka, Croatia
Athens, Greece
Thessaloniki, Greece
New Delhi, India
Akashi City, Hyogo, Japan
Tampa, Florida, United States
Seoul, Korea, Republic Of
Kuala Lumpur, Malaysia
Springdale, Arkansas, United States
Athens, Attiki, Greece
Sakai Shi, Osaka, Japan
Brescia, Italy
Hefei, Anhui, China
Bengbu, Anhui, China
Hefei, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Xiamen, Fujian, China
Hefei, Anhui, China
Xiamen, Fujian, China
Shijiazhuang, Hebei, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Harbin, Heilongjiang, China
Liuzhou, Guangxi, China
Zhengzhou, Henan, China
Xuzhou, Jiangsu, China
Nanchang, Jiangxi, China
Wuhan, Hubei, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Nanjing, Jiangsu, China
Xi'an, Shaanxi, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Qingdao, Shandong, China
Shanghai, Shanghai, China
Taiyuan, Shanxi, China
Urumchi, Xinjiang, China
Urumqi, Xinjiang, China
Kunming, Yunnan, China
Hangzhou, Zhejiang, China
Lowenstein, Germany
Hangzhou, Zhejiang, China
Neuruppin, Germany
Bangalore, India
Vancouver, British Columbia, Canada
Palmerston North, New Zealand
Guangzhou, Guangdong, China
Gent, Vlaams Brabant, Belgium
Guangzhou, Guangdong, China
Taiyuan, Shanxi, China
Maywood, Illinois, United States
Athens, Greece
Brescia, Italy
Candiolo, Italy
Bay Pines, Florida, United States
Leicester, United Kingdom
Großhansdorf, Schleswig Holstein, Germany
Birmingham, England, United Kingdom
Genova, Italy
Chengdu, Sichuan, China
Fuzhou, Fujian, China
Luzhou, Sichuan, China
Fuzhou, Fujian, China
Nantong, Jiangsu, China
Kunming, Yunnan, China
Chongqing, Chongqing, China
Galway, Ireland
Shenyang, Liaoning, China
Prescott Valley, Arizona, United States
Albany, New York, United States
Milano, Italy
Cleveland, Ohio, United States
Columbus, Georgia, United States
Be'er Sheva, Israel
Bari, Italy
Rome, Italy
Norwich, Connecticut, United States
Bologna, Italy
Fairfield, Ohio, United States
Springdale, Arkansas, United States
Parma, Italy
Barretos, Brazil
Taizhou, Zhejiang, China
Marseille, France
Varese, Italy
Daegu, Korea, Republic Of
Goyang Si, Korea, Republic Of
Roma, Italy
Rozzano, Italy
Madrid, Spain
George Town, Penang, Malaysia
Petaling Jaya, Selangor, Malaysia
Mexico, Distrito Federal, Mexico
Madrid, Spain
Madrid, Spain
Bahcelievler, Turkey
Rosario, Santa Fe, Argentina
Hyde Park, Australia
Natal, Rio Grande Do Norte, Brazil
Chemnitz, Germany
Hamburg, Germany
Ulm, Germany
Nagoya, Japan
Nagoya, Japan
Merriam, Kansas, United States
Ankara, Turkey
Guadalajara, Jalisco, Mexico
Amsterdam, Netherlands
Durham, North Carolina, United States
Helsinki, Finland
Timioara, Romania
Germantown, Tennessee, United States
Edegem, Antwerpen, Belgium
Seoul, Korea, Republic Of
Seoul, Korea, Republic Of
Mcpherson, Kansas, United States
Hackensack, New Jersey, United States
Montpellier, France
Floreti, Romania
Kocaeli, Turkey
Tbilisi, Georgia
Hackensack, New Jersey, United States
Arlington, Texas, United States
Olomouc, Czechia
Jacksonville, Florida, United States
Ostrava, Czechia
Park Ridge, Illinois, United States
Ballarat, Victoria, Australia
Linz, Austria
Surrey, England, United Kingdom
Tallahassee, Florida, United States
Frankfurt, Germany
Utrecht, Netherlands
Budapest, Hungary
Praha, Czechia
Tucson, Arizona, United States
Bay Pines, Florida, United States
Tampa, Florida, United States
Harderwijk, Netherlands
Cusco, Peru
Vancouver, British Columbia, Canada
Safed, Israel
Gdańsk, Poland
Toronto, Ontario, Canada
Urumqi, Xinjiang, China
Sagamihara, Kanagawa, Japan
Kanazawa, Japan
Nijmegen, Netherlands
Chongqing, Chongqing, China
Jerusalem, Israel
Johor Bahru, Johor, Malaysia
Mamak, Turkey
Sarasota, Florida, United States
Marietta, Georgia, United States
Goshen, Indiana, United States
East Brunswick, New Jersey, United States
Sioux Falls, South Dakota, United States
Shanghai, China
Yinchuan, Ningxia, China
Palmerston North, New Zealand
Aventura, Florida, United States
Jacksonville Beach, Florida, United States
Cheongju Si, Korea, Republic Of
Wichita, Kansas, United States
Boston, Massachusetts, United States
Munchen, Bayern, Germany
Bengbu, Anhui, China
Hefei, Anhui, China
Hefei, Anhui, China
Hefei, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Guangzhou, Guangdong, China
Fuzhou, Fujian, China
Nanning, Guangxi, China
Nanning, Guangxi, China
Shijiazhuang, Hebei, China
Harbin, Heilongjiang, China
Harbin, Heilongjiang, China
Guangzhou, Guangdong, China
Xinxiang, Henan, China
Guangzhou, Guangdong, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Wuhan, Hubei, China
Wuhan, Hubei, China
Wuhan, Hubei, China
Changsha, Hunan, China
Changsha, Hunan, China
Nanjing, Jiangsu, China
Shenzhen, Guangdong, China
Liuzhou, Guangxi, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nantong, Jiangsu, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nanchang, Jiangxi, China
Xuzhou, Jiangsu, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Changchun, Jilin, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Xi'an, Shaanxi, China
Shanghai, Shanghai, China
Xi'an, Shaanxi, China
Jinan, Shandong, China
Jinan, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Linyi, Shandong, China
Linyi, Shandong, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Shanghai, Shanghai, China
Taiyuan, Shanxi, China
Urumchi, Xinjiang, China
Luzhou, Sichuan, China
Kunming, Yunnan, China
Urumchi, Xinjiang, China
Kunming, Yunnan, China
Kunming, Yunnan, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Qingdao, China
Qingdao, China
Gießen, Germany
Zhengzhou, Henan, China
Hangzhou, Zhejiang, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Taizhou, Zhejiang, China
Taiyuan, Shanxi, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Taizhou, Zhejiang, China
Xiamen, Fujian, China
Xiamen, Fujian, China
Nanning, Guangxi, China
Xi'an, Shaanxi, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Yinchuan, Ningxia, China
Rotterdam, Netherlands
Rotterdam, Netherlands
Quezon City, Philippines
Beograd, Serbia
Beijing, Beijing, China
Farkasgyepu, Hungary
Guildford, England, United Kingdom
Foxboro, Massachusetts, United States
Ahemdabad, India
Aurora, Colorado, United States
Aurangabad, India
Hyderabad, India
Hyderabad, India
Kochi, India
Vancouver, British Columbia, Canada
Zhengzhou, Henan, China
New Delhi, India
Nagoya, Japan
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Shenyang, Liaoning, China
Nagoya, Japan
Akashi City, Hyogo, Japan
Floresti, Romania
Nanning, Guangxi, China
Sofia, Bulgaria
Sendai, Miyagi, Japan
Pesaro, Italy
Montreal, Quebec, Canada
Dublin, Ireland
Guimaraes, Portugal
South Weymouth, Massachusetts, United States
Angers Cedex 02, France
Boulogne Billancourt, France
Caen Cedex 5, France
Limoges Cedex, France
Marseille, France
Cerritos, California, United States
Nankoku Shi, Japan
Kuala Lumpur, Malaysia
Rennes Cedex 9, France
Taipei City, Taiwan
Saint Herblain, France
Mumbai, India
Varanasi, India
Tallahassee, Florida, United States
Nagasaki Shi, Nagasaki, Japan
Zagreb, Croatia
Bacolod City, Philippines
Krung Thep Maha Nakhon, Thailand
Heilbronn, Germany
Peiraias, Greece
Zsfat, Israel
Hemer, Germany
Pesaro, Italy
Kassel, Germany
Mainz, Germany
Munchen, Germany
Offenbach, Germany
Oldenburg, Germany
Suwon Si, Korea, Republic Of
Athens, Greece
Lima, Peru
Madrid, Spain
Gavle, Sweden
Taichung, Taiwan
Heraklion, Greece
Larissa, Greece
Krakow, Poland
Den Haag, Netherlands
Lublin, Poland
Olsztyn, Poland
Poznan, Poland
Coimbra, Portugal
Guimaraes, Portugal
Arequipa, Peru
Taipei City, Taiwan
Malatya, Turkey
Mamak, Turkey
Lone Tree, Colorado, United States
Porto, Portugal
Porto, Portugal
Arequipa, Peru
Mangalore, India
Badalona, Spain
Jerez De La Frontera, Spain
Lhospitalet De Llobregat, Spain
Mysore, India
Fukushima Shi, Japan
Osaka, Japan
Merriam, Kansas, United States
Belgrade, Serbia
Nanning, Guangxi, China
Vejle, Denmark
Augsburg, Germany
Jaipur, India
Drammen, Norway
Patna, India
Bat Galim, Israel
Milan, Italy
Alanya, Turkey
Pune, India
Iloilo City, Philippines
Manchester, United Kingdom
Waterford, Ireland
Tel Aviv, Israel
Firenze, Italy
Surrey, United Kingdom
Toon Shi, Ehime, Japan
Seoul, Korea, Republic Of
Kashihara, Nara, Japan
George Town, Penang, Malaysia
Cebu City, Philippines
Kragujevac, Serbia
Uzice, Serbia
Taipei City, Taiwan
Iwakuni, Japan
Osaka, Japan
Toyama, Japan
Louisville, Kentucky, United States
Covington, Louisiana, United States
Brighton, Massachusetts, United States
Methuen, Massachusetts, United States
Birmingham, United Kingdom
London, United Kingdom
Los Alamitos, California, United States
Shenyang, Liaoning, China
Pittsburgh, Pennsylvania, United States
Jinan, Shandong, China
Bengbu, Anhui, China
Beijing, Beijing, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Nanjing, Jiangsu, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Nanning, Guangxi, China
Wuhan, Hubei, China
Changsha, Hunan, China
Nanchang, Jiangxi, China
Nanchang, Jiangxi, China
Amberg, Germany
Hangzhou, Zhejiang, China
Macon, Georgia, United States
Merriam, Kansas, United States
Longmont, Colorado, United States
Port Macquarie, Australia
Barretos, Brazil
Hangzhou, Zhejiang, China
Hefei, Anhui, China
Harbin, Heilongjiang, China
Taizhou, Zhejiang, China
Nanjing, Jiangsu, China
Central, Hong Kong
Belgrade, Serbia
Tbilisi, Georgia
Gaziantep, Turkey
Chemnitz, Germany
Perugia, Italy
Changchun, Jilin, China
Fukushima Shi, Japan
Iwakuni, Japan
Osaka, Japan
Busan Si, Korea, Republic Of
Seoul, Korea, Republic Of
Nishinomiya Shi, Hyogo, Japan
Kielce, Poland
Sendai, Miyagi, Japan
Kashihara, Nara, Japan
Lublin, Poland
Olsztyn, Poland
Badalona, Spain
Sakai Shi, Osaka, Japan
Uzice, Serbia
Poznan, Poland
Bangkok, Thailand
Porto, Portugal
Xiamen, Fujian, China
Shenyang, Liaoning, China
Malatya, Turkey
Hong Kong, Hong Kong
Candiolo, Italy
Taiyuan, Shanxi, China
Bad Homburg, Germany
Braunschweig, Germany
Belgrano, Buenos Aires, Argentina
Petaling Jaya, Selangor, Malaysia
Singapore, Singapore
Ankara, Turkey
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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