Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Launched by MIRATI THERAPEUTICS INC. · Oct 30, 2020
Trial Information
Current as of September 09, 2025
Recruiting
Keywords
ClinConnect Summary
The KRYSTAL-7 trial is studying a new treatment for patients with advanced non-small cell lung cancer (NSCLC) that has a specific mutation called KRAS G12C. The trial has two parts: the Phase 2 part is looking at how well the drug adagrasib works alone or when combined with another medication called pembrolizumab. This part is for patients who have not received prior treatment and have any level of a protein called PD-L1. The Phase 3 part will compare the effects of adagrasib combined with pembrolizumab against pembrolizumab alone in patients with similar cancer characteristics but with a higher level of PD-L1.
To be eligible for this trial, participants must have a confirmed diagnosis of advanced or metastatic NSCLC with the KRAS G12C mutation. They should not have received prior systemic treatments for their cancer, and specific criteria regarding brain health must be met. Participants can expect close monitoring from the research team throughout the study, and their health will be evaluated regularly to determine how well the treatment is working. This trial is currently recruiting patients, and it aims to find effective treatment options for those facing this challenging condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Phase 2: Histologically confirmed diagnosis of unresectable or metastatic NSCLC with KRAS G12C mutation and any PD-L1 TPS
- • Phase 3: Histologically confirmed diagnosis of unresectable or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS \>=50%
- • Phase 3: Presence of evaluable or measurable disease per RECIST
- * Phase 3: CNS Inclusion - Based on screening brain imaging, patients must have one of the following:
- • 1. No evidence of brain metastases
- • 2. Untreated brain metastases not needing immediate local therapy
- • 3. Previously treated brain metastases not needing immediate local therapy
- Exclusion Criteria:
- • Phase 2 and Phase 3: Prior systemic treatment for locally advanced or metastatic NSCLC including chemotherapy, immune checkpoint inhibitor therapy, or a therapy targeting KRAS G12C mutation (e.g., AMG 510).
- • Phase 2: Active brain metastases
- * Phase 3: Patients with known central nervous system (CNS) lesions must not have any of the following:
- • 1. Any untreated brain lesions \> 1.0 cm in size
- • 2. Any brainstem lesions
- • 3. Ongoing use of systemic corticosteroids for control of symptoms of brain lesions at a total daily dose of \> 10 mg of prednisone (or equivalent) prior to randomization.
- • 4. Have poorly controlled (\> 1/week) generalized or complex partial seizures, or manifest neurologic progression due to brain lesions notwithstanding CNS-directed therapy
- • Phase 3: Radiation to the lung \> 30 Gy within 6 months prior to the first dose of study treatment
About Mirati Therapeutics Inc.
Mirati Therapeutics, Inc. is a biopharmaceutical company dedicated to discovering and developing transformative therapies for patients with genetically defined cancers. With a strong focus on precision medicine, Mirati leverages advanced science and innovative technologies to identify and target specific genetic mutations driving cancer progression. The company’s robust pipeline includes novel small molecules and immunotherapies, aimed at addressing significant unmet medical needs and improving patient outcomes. Committed to advancing oncology research, Mirati collaborates with healthcare professionals and research institutions to bring cutting-edge treatments from the lab to the clinic.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Tbilisi, Georgia
Monchengladbach, Germany
Istanbul, Turkey
Izmir, Turkey
Fort Myers, Florida, United States
Esslingen, Baden Wuerttemberg, Germany
Long Beach, California, United States
Whittier, California, United States
Miami, Florida, United States
Orlando, Florida, United States
Vratsa, Bulgaria
London, Ontario, Canada
Giessen, Germany
Krakow, Poland
Taichung, Taiwan
Gabrovo, Bulgaria
Chai Wan, Hong Kong
Dublin, Ireland
Plovdiv, Bulgaria
Chicago, Illinois, United States
Nashville, Tennessee, United States
Lexington, Kentucky, United States
Lisbon, Portugal
Porto, Portugal
Prescott Valley, Arizona, United States
Cerritos, California, United States
Los Alamitos, California, United States
Los Angeles, California, United States
Rancho Mirage, California, United States
San Francisco, California, United States
Jacksonville, Florida, United States
Westwood, Kansas, United States
Wichita, Kansas, United States
Baltimore, Maryland, United States
Durham, North Carolina, United States
Belleville, New Jersey, United States
Teaneck, New Jersey, United States
Cleveland, Ohio, United States
Kettering, Ohio, United States
Allentown, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Nashville, Tennessee, United States
Austin, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Fairfax, Virginia, United States
Vancouver, Washington, United States
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Bedford Park, Australia
Clayton, Australia
Linz, Austria
Edegem, Belgium
Porto Alegre, Rio Grande Do Sul, Brazil
Monteria, Colombia
Ostrava, Czechia
Heidelberg, Germany
West Palm Beach, Florida, United States
Garran, Australia
Tigard, Oregon, United States
Amarillo, Texas, United States
Long Beach, California, United States
Germantown, Tennessee, United States
Denison, Texas, United States
Buenos Aires, Argentina
Woolloongabba, Australia
Wien, Austria
Beijing, Beijing, China
Chongqing, Chongqing, China
Kunming, Yunnan, China
Tampere, Finland
Kowloon, Hong Kong
Belagavi, India
Jaipur, India
Kolkata, India
Madurai, India
Busan, Korea, Republic Of
Suwon Si, Korea, Republic Of
Coimbra, Portugal
Sankt Gallen, Switzerland
London, United Kingdom
Edmonton, Alberta, Canada
Barcelona, Spain
Burnsville, Minnesota, United States
Jackson, Mississippi, United States
Edirne, Turkey
Honolulu, Hawaii, United States
Praha 2, Czechia
La Tronche, France
Rajkot, India
Molo, Philippines
Pretoria, Gauteng, South Africa
Madison, Wisconsin, United States
Honolulu, Hawaii, United States
Albany, New York, United States
Dallas, Texas, United States
Wollongong, Australia
Sao Jose Do Rio Preto, Brazil
Sofia, Bulgaria
Tyler, Texas, United States
Sioux Falls, South Dakota, United States
Incheon, Gyeonggi Do, Korea, Republic Of
London, England, United Kingdom
Pensacola, Florida, United States
West Palm Beach, Florida, United States
Athens, Georgia, United States
Omaha, Nebraska, United States
Salem, Oregon, United States
Fredericksburg, Texas, United States
Lone Tree, Colorado, United States
Fredericksburg, Texas, United States
Anaheim, California, United States
Safford, Arizona, United States
Denver, Colorado, United States
Sarasota, Florida, United States
Kingman, Kansas, United States
Hasselt, Belgium
Abilene, Texas, United States
Beijing, Beijing, China
East Brunswick, New Jersey, United States
Laguna Hills, California, United States
Long Beach, California, United States
Santa Ana, California, United States
Colorado Springs, Colorado, United States
Centennial, Colorado, United States
Colorado Springs, Colorado, United States
Naples, Florida, United States
Arlington Heights, Illinois, United States
Chanute, Kansas, United States
Newton, Kansas, United States
Parsons, Kansas, United States
Louisville, Kentucky, United States
Covington, Louisiana, United States
Covington, Louisiana, United States
Omaha, Nebraska, United States
Papillion, Nebraska, United States
Somerset, New Jersey, United States
Somerset, New Jersey, United States
Somerset, New Jersey, United States
Cincinnati, Ohio, United States
Hendersonville, Tennessee, United States
Hermitage, Tennessee, United States
Nashville, Tennessee, United States
Nashville, Tennessee, United States
Shelbyville, Tennessee, United States
Arlington, Texas, United States
Austin, Texas, United States
Irving, Texas, United States
Longview, Texas, United States
Roma, Italy
Tbilisi, Georgia
Immenstadt, Bayern, Germany
Saint Augustine, Florida, United States
Stuart, Florida, United States
Pratt, Kansas, United States
Edina, Minnesota, United States
Austin, Texas, United States
Bonita Springs, Florida, United States
Jacksonville, Florida, United States
Naples, Florida, United States
Tigard, Oregon, United States
Salina, Kansas, United States
Wellington, Kansas, United States
Las Vegas, Nevada, United States
Lisboa, Portugal
Bedford, Texas, United States
Port Charlotte, Florida, United States
Carrollton, Georgia, United States
Whittier, California, United States
Littleton, Colorado, United States
The Woodlands, Texas, United States
Makati City, Philippines
Lebanon, Tennessee, United States
Pueblo, Colorado, United States
Bradenton, Florida, United States
Murfreesboro, Tennessee, United States
Safford, Arizona, United States
Safford, Arizona, United States
Safford, Arizona, United States
Fleming Island, Florida, United States
Fountain Valley, California, United States
Cape Coral, Florida, United States
Celebration, Florida, United States
Fort Myers, Florida, United States
Fort Myers, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Venice, Florida, United States
Boulder, Colorado, United States
Lakewood, Colorado, United States
Vero Beach, Florida, United States
Wellington, Florida, United States
Venice, Florida, United States
Hiram, Georgia, United States
Liberal, Kansas, United States
Wichita, Kansas, United States
Cartersville, Georgia, United States
Douglasville, Georgia, United States
Winfield, Kansas, United States
Grand Island, Nebraska, United States
Portland, Oregon, United States
Omaha, Nebraska, United States
Somerset, New Jersey, United States
Cincinnati, Ohio, United States
Dickson, Tennessee, United States
Franklin, Tennessee, United States
Portland, Oregon, United States
Nashville, Tennessee, United States
Gallatin, Tennessee, United States
Amarillo, Texas, United States
Arlington, Texas, United States
El Paso, Texas, United States
Alexandria, Virginia, United States
Arlington, Virginia, United States
Gainesville, Virginia, United States
Leesburg, Virginia, United States
Pamplona, Navarre, Spain
Thornton, Colorado, United States
Nashville, Tennessee, United States
El Paso, Texas, United States
Daytona Beach, Florida, United States
Austin, Texas, United States
Bedford, Texas, United States
Omaha, Nebraska, United States
Independence, Kansas, United States
Las Vegas, Nevada, United States
Jacksonville, Florida, United States
Goodyear, Arizona, United States
Varese, Italy
Toruń, Poland
Midland, Texas, United States
Santiago De Compostela, Spain
Wichita Falls, Texas, United States
A Coruña, Spain
Timisoara, Romania
Las Vegas, Nevada, United States
Smyrna, Tennessee, United States
El Paso, Texas, United States
Napoli, Italy
Parma, Italy
Roma, Italy
Otwock, Poland
Skorzewo, Poland
Sevilla, Spain
San Francisco, California, United States
Jacksonville, Florida, United States
Roma, Italy
Valencia, Spain
Manchester, England, United Kingdom
Vienna, Austria
Suwon Si, Korea, Republic Of
Tyler, Texas, United States
Valencia, Spain
Suwon Si, Gyeonggi Do, Korea, Republic Of
Milan, Italy
Busan, Korea, Republic Of
Santa Rosa, California, United States
Anaheim, California, United States
Jacksonville, Florida, United States
Miami, Florida, United States
Atlanta, Georgia, United States
Marietta, Georgia, United States
Peoria, Illinois, United States
Norwich, Connecticut, United States
Rochester, Minnesota, United States
Louisville, Kentucky, United States
Baton Rouge, Louisiana, United States
Jackson, Mississippi, United States
Salem, Oregon, United States
Cincinnati, Ohio, United States
Spartanburg, South Carolina, United States
Salt Lake City, Utah, United States
Huntington, West Virginia, United States
Madison, Wisconsin, United States
Ballarat, Australia
Klagenfurt Am Woerthersee, Austria
Hasselt, Belgium
Roeselare, Belgium
Gabrovo, Bulgaria
Haskovo, Bulgaria
Plovdiv, Bulgaria
Temuco, Chile
Medellin, Colombia
Ottawa, Ontario, Canada
Toronto, Ontario, Canada
Tbilisi, Georgia
Grohansdorf, Germany
Esslingen, Germany
Jena, Germany
Tatabanya, Hungary
Frankfurt Am Main, Germany
Giessen, Germany
Holon, Israel
Jerusalem, Israel
Bari, Italy
Padova, Italy
Perugia, Italy
Cheongju Si, Korea, Republic Of
Milano, Italy
Dordrecht, Netherlands
Harderwijk, Netherlands
Seoul, Korea, Republic Of
Arequipa, Peru
Otwock, Poland
Kielce, Poland
Warszawa, Poland
Timișoara, Romania
Barcelona, Spain
Leon, Spain
Lisbon, Portugal
Antalya, Turkey
Sevilla, Spain
Birmingham, United Kingdom
Edinburgh, United Kingdom
Bahcelievler, Turkey
Tucson, Arizona, United States
Stockton, California, United States
London, United Kingdom
Washington, District Of Columbia, United States
Tallahassee, Florida, United States
Tampa, Florida, United States
Weston, Florida, United States
Las Vegas, Nevada, United States
Jacksonville, Florida, United States
Columbus, Ohio, United States
Bronx, New York, United States
Rhinebeck, New York, United States
Houston, Texas, United States
Providence, Rhode Island, United States
Lajeado, Rio Grande Do Sul, Brazil
Richmond, Virginia, United States
Porto Alegre, Argentina
Vratsa, Bulgaria
Praha 8 Liben, Czechia
Brest, France
Edmonton, Alberta, Canada
Chemnitz, Germany
Mulhouse, France
Paris Cedex 05, France
Kempten, Germany
Lubeck, Germany
Rehovot, Israel
Cork, Ireland
Dublin, Ireland
Dublin, Ireland
Monza, Italy
Ravenna, Italy
Tel Aviv, Israel
Bologna, Italy
Trujillo, La Libertad, Peru
Mexico, Distrito Federal, Mexico
Cercado De Lima, Lima, Peru
Skorzewo, Poland
Torun, Poland
Nijmegen, Netherlands
Barcelona, Spain
Malaga, Spain
Valencia, Spain
Taichung City, Taiwan
Tainan City, Taiwan
Taoyuan, Taiwan
Lisbon, Portugal
Edirne, Turkey
Istanbul, Turkey
London, United Kingdom
Bornova, Turkey
Cankaya, Turkey
Singapore, Singapore
Bilbao, Spain
Burgos, Spain
Jung Gu, Korea, Republic Of
Utrecht, Netherlands
Valencia, Spain
Creteil, France
Sisli, Turkey
Safford, Arizona, United States
El Dorado, Kansas, United States
Beer Sheva, Israel
Hořovice, Central Bohemian, Czechia
Denver, Colorado, United States
Orlando, Florida, United States
Pensacola, Florida, United States
Klagenfurt, Carinthia, Austria
Málaga, Spain
Genova, Italy
Stockton, California, United States
Leicester, United Kingdom
Meldola, Italy
A Coruna, Spain
Taipei City, Taiwan
Fort Myers, Florida, United States
Chicago, Illinois, United States
Park Ridge, Illinois, United States
Lexington, Kentucky, United States
Burnsville, Minnesota, United States
Minneapolis, Minnesota, United States
Minneapolis, Minnesota, United States
Odessa, Texas, United States
Eugene, Oregon, United States
The Woodlands, Texas, United States
Rio Cuarto, Argentina
Ijui, Brazil
Rio De Janeiro, Brazil
Sao Paolo, Brazil
Olomouc, Czechia
Saint Herblain, France
Strasbourg Cedex, France
Tours Cedex 9, France
Villejuif, France
Batumi, Georgia
Aviano, Italy
Firenze, Italy
Meldola, Italy
Napoli, Italy
Seoul, Korea, Republic Of
Seoul, Korea, Republic Of
Monterrey, Mexico
Miraflores, Lima, Peru
San Isidro, Lima, Peru
Afula, Israel
Surquillo, Lima, Peru
Vila Nova De Gaia, Portugal
Cluj Napoca, Romania
Santander, Spain
Santiago De Compostela, Spain
Ankara, Turkey
Izmir, Turkey
Gdansk, Poland
Jerusalem, Israel
Warszawa, Poland
Madrid, Spain
Tainan, Taiwan
Kent, United Kingdom
Gyongyos, Hungary
Limerick, Ireland
Taichung, Taiwan
Barcelona, Spain
Waterford, Ireland
Las Palmas De Gran Canaria, Spain
Altindag, Turkey
Niles, Illinois, United States
San Francisco, California, United States
Boston, Massachusetts, United States
Gent, Belgium
Santiago, Chile
Horovice, Czechia
Farkasgyepu, Hungary
Torokbalint, Hungary
Athens, Georgia, United States
Milan, Italy
Zwolle, Netherlands
Barcelona, Spain
Madrid, Spain
Busan, Korea, Republic Of
Lublin, Poland
A Coruña, La Coruña, Spain
Porto, Portugal
Teaneck, New Jersey, United States
Galway, Ireland
Taoyuan, Taiwan
Haskovo, Bulgaria
Koln, Germany
Chicago, Illinois, United States
Osaka, Japan
San Isidro, Lima, Peru
Haskovo, Bulgaria
Pula, Croatia
Odense, Denmark
Soenderborg, Denmark
Hong Kong, Hong Kong
Seoul, Korea, Republic Of
Oslo, Norway
Milford, Massachusetts, United States
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Johannesburg, Gauteng, South Africa
Taipei City, Taiwan
Kassel, Hessen, Germany
Roma, Italy
San Francisco, California, United States
Villars Sur Glane, Switzerland
Bedford Park, Australia
Port Elizabeth, Eastern Cape, South Africa
Seoul, Korea, Republic Of
Kempten, Bavaria, Germany
Amsterdam, Noord Holland, Netherlands
Tainan City, Taiwan
Maywood, Illinois, United States
Charleston, South Carolina, United States
Vienna, Austria
Budapest, Hungary
Budapest, Hungary
Xiamen, Fujian, China
Nagasaki Shi, Nagasaki, Japan
Budapest, Hungary
Kanazawa, Japan
Nankoku Shi, Japan
Monterrey, Mexico
Rotterdam, Netherlands
Ahmedabad, India
Baltimore, Maryland, United States
Wollongong, New South Wales, Australia
Ottawa, Ontario, Canada
Los Alamitos, California, United States
Jesus Maria, Lima, Peru
Sremska Kamenica, Serbia
Niles, Illinois, United States
Goshen, Indiana, United States
Covington, Louisiana, United States
Bronx, New York, United States
Cincinnati, Ohio, United States
Kettering, Ohio, United States
Dallas, Texas, United States
Denison, Texas, United States
Fairfax, Virginia, United States
Richmond, Indiana, United States
Woolloongabba, Queensland, Australia
Gyöngyös, Hungary
Afula, Israel
Haifa, Israel
Goyang Si, Korea, Republic Of
Rotterdam, Zuid Holland, Netherlands
Harderwijk, Netherlands
Lublin, Poland
Lübeck, Schleswig Holstein, Germany
Hemer, Germany
Sagamihara, Kanagawa, Japan
Eugene, Oregon, United States
Santa Rosa, California, United States
Oldenburg, Germany
Odessa, Texas, United States
Garran, Australia
Torokbalint, Hungary
Dublin, Ireland
Reẖovot, Israel
Meldola, Forli Cesena, Italy
Daegu, Korea, Republic Of
L'hospitalet De Llobregat, Barcelona, Spain
Tampa, Florida, United States
Austin, Texas, United States
Rijeka, Croatia
Athens, Greece
Thessaloniki, Greece
New Delhi, India
Springdale, Arkansas, United States
Athens, Attiki, Greece
Akashi City, Hyogo, Japan
Seoul, Korea, Republic Of
Kuala Lumpur, Malaysia
Sakai Shi, Osaka, Japan
Brescia, Italy
Hefei, Anhui, China
Bengbu, Anhui, China
Hefei, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Hefei, Anhui, China
Xiamen, Fujian, China
Xiamen, Fujian, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Liuzhou, Guangxi, China
Shijiazhuang, Hebei, China
Harbin, Heilongjiang, China
Zhengzhou, Henan, China
Beijing, Beijing, China
Xuzhou, Jiangsu, China
Wuhan, Hubei, China
Nanjing, Jiangsu, China
Nanchang, Jiangxi, China
Xi'an, Shaanxi, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Taiyuan, Shanxi, China
Urumchi, Xinjiang, China
Urumqi, Xinjiang, China
Kunming, Yunnan, China
Linyi, Shandong, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Qingdao, Shandong, China
Palmerston North, New Zealand
Vancouver, British Columbia, Canada
Lowenstein, Germany
Neuruppin, Germany
Bangalore, India
Gent, Vlaams Brabant, Belgium
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Taiyuan, Shanxi, China
Maywood, Illinois, United States
Athens, Greece
Brescia, Italy
Candiolo, Italy
Leicester, United Kingdom
Bay Pines, Florida, United States
Birmingham, England, United Kingdom
Großhansdorf, Schleswig Holstein, Germany
Genova, Italy
Chengdu, Sichuan, China
Luzhou, Sichuan, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Nantong, Jiangsu, China
Galway, Ireland
Chongqing, Chongqing, China
Shenyang, Liaoning, China
Milano, Italy
Prescott Valley, Arizona, United States
Kunming, Yunnan, China
Cleveland, Ohio, United States
Albany, New York, United States
Be'er Sheva, Israel
Bari, Italy
Bologna, Italy
Columbus, Georgia, United States
Norwich, Connecticut, United States
Springdale, Arkansas, United States
Rome, Italy
Fairfield, Ohio, United States
Barretos, Brazil
Taizhou, Zhejiang, China
Marseille, France
Varese, Italy
Parma, Italy
Daegu, Korea, Republic Of
Goyang Si, Korea, Republic Of
George Town, Penang, Malaysia
Petaling Jaya, Selangor, Malaysia
Mexico, Distrito Federal, Mexico
Madrid, Spain
Madrid, Spain
Madrid, Spain
Bahcelievler, Turkey
Merriam, Kansas, United States
Roma, Italy
Rozzano, Italy
Rosario, Santa Fe, Argentina
Hyde Park, Australia
Natal, Rio Grande Do Norte, Brazil
Ankara, Turkey
Chemnitz, Germany
Hamburg, Germany
Ulm, Germany
Nagoya, Japan
Nagoya, Japan
Helsinki, Finland
Durham, North Carolina, United States
Edegem, Antwerpen, Belgium
Timioara, Romania
Germantown, Tennessee, United States
Guadalajara, Jalisco, Mexico
Amsterdam, Netherlands
Floreti, Romania
Seoul, Korea, Republic Of
Seoul, Korea, Republic Of
Mcpherson, Kansas, United States
Hackensack, New Jersey, United States
Kocaeli, Turkey
Jacksonville, Florida, United States
Park Ridge, Illinois, United States
Hackensack, New Jersey, United States
Montpellier, France
Tbilisi, Georgia
Arlington, Texas, United States
Olomouc, Czechia
Ballarat, Victoria, Australia
Linz, Austria
Budapest, Hungary
Surrey, England, United Kingdom
Ostrava, Czechia
Tallahassee, Florida, United States
Frankfurt, Germany
Utrecht, Netherlands
Praha, Czechia
Tucson, Arizona, United States
Gdańsk, Poland
Tampa, Florida, United States
Bay Pines, Florida, United States
Cusco, Peru
Harderwijk, Netherlands
Vancouver, British Columbia, Canada
Safed, Israel
Toronto, Ontario, Canada
Jerusalem, Israel
Johor Bahru, Johor, Malaysia
Urumqi, Xinjiang, China
Sagamihara, Kanagawa, Japan
Kanazawa, Japan
Nijmegen, Netherlands
Chongqing, Chongqing, China
Mamak, Turkey
Sarasota, Florida, United States
Marietta, Georgia, United States
Goshen, Indiana, United States
East Brunswick, New Jersey, United States
Sioux Falls, South Dakota, United States
Shanghai, China
Yinchuan, Ningxia, China
Palmerston North, New Zealand
Cheongju Si, Korea, Republic Of
Boston, Massachusetts, United States
Wichita, Kansas, United States
Munchen, Bayern, Germany
Bengbu, Anhui, China
Aventura, Florida, United States
Jacksonville Beach, Florida, United States
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Fuzhou, Fujian, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Liuzhou, Guangxi, China
Hefei, Anhui, China
Hefei, Anhui, China
Hefei, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Xinxiang, Henan, China
Nanning, Guangxi, China
Nanning, Guangxi, China
Shijiazhuang, Hebei, China
Harbin, Heilongjiang, China
Harbin, Heilongjiang, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Nanjing, Jiangsu, China
Zhengzhou, Henan, China
Wuhan, Hubei, China
Wuhan, Hubei, China
Wuhan, Hubei, China
Changsha, Hunan, China
Changsha, Hunan, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nanchang, Jiangxi, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nantong, Jiangsu, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Changchun, Jilin, China
Changchun, Jilin, China
Xi'an, Shaanxi, China
Xuzhou, Jiangsu, China
Xi'an, Shaanxi, China
Jinan, Shandong, China
Jinan, Shandong, China
Linyi, Shandong, China
Linyi, Shandong, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Nanchang, Jiangxi, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Luzhou, Sichuan, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Taiyuan, Shanxi, China
Urumchi, Xinjiang, China
Kunming, Yunnan, China
Kunming, Yunnan, China
Kunming, Yunnan, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Taizhou, Zhejiang, China
Qingdao, China
Qingdao, China
Gießen, Germany
Zhengzhou, Henan, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Taiyuan, Shanxi, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Urumchi, Xinjiang, China
Taizhou, Zhejiang, China
Xiamen, Fujian, China
Nanning, Guangxi, China
Xi'an, Shaanxi, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Beograd, Serbia
Rotterdam, Netherlands
Rotterdam, Netherlands
Quezon City, Philippines
Guildford, England, United Kingdom
Xiamen, Fujian, China
Beijing, Beijing, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Yinchuan, Ningxia, China
Farkasgyepu, Hungary
Foxboro, Massachusetts, United States
Aurora, Colorado, United States
Vancouver, British Columbia, Canada
Zhengzhou, Henan, China
Nanjing, Jiangsu, China
Ahemdabad, India
Aurangabad, India
Hyderabad, India
Hyderabad, India
Kochi, India
New Delhi, India
Nanjing, Jiangsu, China
Shenyang, Liaoning, China
Nagoya, Japan
Nagoya, Japan
Akashi City, Hyogo, Japan
Sendai, Miyagi, Japan
Nanning, Guangxi, China
Sofia, Bulgaria
Floresti, Romania
Cerritos, California, United States
Pesaro, Italy
South Weymouth, Massachusetts, United States
Angers Cedex 02, France
Boulogne Billancourt, France
Caen Cedex 5, France
Limoges Cedex, France
Marseille, France
Rennes Cedex 9, France
Saint Herblain, France
Mumbai, India
Varanasi, India
Nagasaki Shi, Nagasaki, Japan
Nankoku Shi, Japan
Kuala Lumpur, Malaysia
Montreal, Quebec, Canada
Dublin, Ireland
Guimaraes, Portugal
Tallahassee, Florida, United States
Zagreb, Croatia
Taipei City, Taiwan
Bacolod City, Philippines
Krung Thep Maha Nakhon, Thailand
Heilbronn, Germany
Peiraias, Greece
Zsfat, Israel
Hemer, Germany
Kassel, Germany
Mainz, Germany
Munchen, Germany
Offenbach, Germany
Pesaro, Italy
Suwon Si, Korea, Republic Of
Oldenburg, Germany
Athens, Greece
Lima, Peru
Krakow, Poland
Lublin, Poland
Olsztyn, Poland
Poznan, Poland
Coimbra, Portugal
Guimaraes, Portugal
Porto, Portugal
Porto, Portugal
Badalona, Spain
Jerez De La Frontera, Spain
Lhospitalet De Llobregat, Spain
Heraklion, Greece
Larissa, Greece
Den Haag, Netherlands
Arequipa, Peru
Taipei City, Taiwan
Madrid, Spain
Gavle, Sweden
Taichung, Taiwan
Lone Tree, Colorado, United States
Malatya, Turkey
Mamak, Turkey
Mangalore, India
Mysore, India
Fukushima Shi, Japan
Osaka, Japan
Belgrade, Serbia
Merriam, Kansas, United States
Arequipa, Peru
Nanning, Guangxi, China
Vejle, Denmark
Jaipur, India
Drammen, Norway
Iloilo City, Philippines
Manchester, United Kingdom
Surrey, United Kingdom
Alanya, Turkey
Augsburg, Germany
Patna, India
Bat Galim, Israel
Milan, Italy
Pune, India
Waterford, Ireland
Tel Aviv, Israel
Firenze, Italy
Toon Shi, Ehime, Japan
Kashihara, Nara, Japan
Iwakuni, Japan
Seoul, Korea, Republic Of
Osaka, Japan
Toyama, Japan
Birmingham, United Kingdom
George Town, Penang, Malaysia
Cebu City, Philippines
Kragujevac, Serbia
Uzice, Serbia
Taipei City, Taiwan
Louisville, Kentucky, United States
London, United Kingdom
Covington, Louisiana, United States
Brighton, Massachusetts, United States
Methuen, Massachusetts, United States
Shenyang, Liaoning, China
Jinan, Shandong, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Taizhou, Zhejiang, China
Tbilisi, Georgia
Chemnitz, Germany
Perugia, Italy
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Nanjing, Jiangsu, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Nanning, Guangxi, China
Wuhan, Hubei, China
Changsha, Hunan, China
Nanchang, Jiangxi, China
Nanchang, Jiangxi, China
Amberg, Germany
Macon, Georgia, United States
Los Alamitos, California, United States
Pittsburgh, Pennsylvania, United States
Bengbu, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Longmont, Colorado, United States
Port Macquarie, Australia
Merriam, Kansas, United States
Barretos, Brazil
Hefei, Anhui, China
Harbin, Heilongjiang, China
Nanjing, Jiangsu, China
Central, Hong Kong
Belgrade, Serbia
Gaziantep, Turkey
Changchun, Jilin, China
Fukushima Shi, Japan
Iwakuni, Japan
Osaka, Japan
Busan Si, Korea, Republic Of
Nishinomiya Shi, Hyogo, Japan
Seoul, Korea, Republic Of
Kielce, Poland
Lublin, Poland
Olsztyn, Poland
Sendai, Miyagi, Japan
Badalona, Spain
Uzice, Serbia
Bangkok, Thailand
Xiamen, Fujian, China
Shenyang, Liaoning, China
Kashihara, Nara, Japan
Sakai Shi, Osaka, Japan
Taiyuan, Shanxi, China
Bad Homburg, Germany
Braunschweig, Germany
Hong Kong, Hong Kong
Candiolo, Italy
Petaling Jaya, Selangor, Malaysia
Singapore, Singapore
Ankara, Turkey
Belgrano, Buenos Aires, Argentina
Poznan, Poland
Porto, Portugal
Malatya, Turkey
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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