Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Launched by MIRATI THERAPEUTICS INC. · Oct 30, 2020
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
The KRYSTAL-7 trial is studying a new treatment for patients with advanced non-small cell lung cancer (NSCLC) that has a specific mutation called KRAS G12C. The trial has two parts: the Phase 2 part is looking at how well the drug adagrasib works alone or when combined with another medication called pembrolizumab. This part is for patients who have not received prior treatment and have any level of a protein called PD-L1. The Phase 3 part will compare the effects of adagrasib combined with pembrolizumab against pembrolizumab alone in patients with similar cancer characteristics but with a higher level of PD-L1.
To be eligible for this trial, participants must have a confirmed diagnosis of advanced or metastatic NSCLC with the KRAS G12C mutation. They should not have received prior systemic treatments for their cancer, and specific criteria regarding brain health must be met. Participants can expect close monitoring from the research team throughout the study, and their health will be evaluated regularly to determine how well the treatment is working. This trial is currently recruiting patients, and it aims to find effective treatment options for those facing this challenging condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Phase 2: Histologically confirmed diagnosis of unresectable or metastatic NSCLC with KRAS G12C mutation and any PD-L1 TPS
- • Phase 3: Histologically confirmed diagnosis of unresectable or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS \>=50%
- • Phase 3: Presence of evaluable or measurable disease per RECIST
- * Phase 3: CNS Inclusion - Based on screening brain imaging, patients must have one of the following:
- • 1. No evidence of brain metastases
- • 2. Untreated brain metastases not needing immediate local therapy
- • 3. Previously treated brain metastases not needing immediate local therapy
- Exclusion Criteria:
- • Phase 2 and Phase 3: Prior systemic treatment for locally advanced or metastatic NSCLC including chemotherapy, immune checkpoint inhibitor therapy, or a therapy targeting KRAS G12C mutation (e.g., AMG 510).
- • Phase 2: Active brain metastases
- * Phase 3: Patients with known central nervous system (CNS) lesions must not have any of the following:
- • 1. Any untreated brain lesions \> 1.0 cm in size
- • 2. Any brainstem lesions
- • 3. Ongoing use of systemic corticosteroids for control of symptoms of brain lesions at a total daily dose of \> 10 mg of prednisone (or equivalent) prior to randomization.
- • 4. Have poorly controlled (\> 1/week) generalized or complex partial seizures, or manifest neurologic progression due to brain lesions notwithstanding CNS-directed therapy
- • Phase 3: Radiation to the lung \> 30 Gy within 6 months prior to the first dose of study treatment
About Mirati Therapeutics Inc.
Mirati Therapeutics, Inc. is a biopharmaceutical company dedicated to discovering and developing transformative therapies for patients with genetically defined cancers. With a strong focus on precision medicine, Mirati leverages advanced science and innovative technologies to identify and target specific genetic mutations driving cancer progression. The company’s robust pipeline includes novel small molecules and immunotherapies, aimed at addressing significant unmet medical needs and improving patient outcomes. Committed to advancing oncology research, Mirati collaborates with healthcare professionals and research institutions to bring cutting-edge treatments from the lab to the clinic.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Durham, North Carolina, United States
Chicago, Illinois, United States
Bronx, New York, United States
Varese, , Italy
Sioux Falls, South Dakota, United States
Edmonton, Alberta, Canada
Norwich, Connecticut, United States
Boston, Massachusetts, United States
Orlando, Florida, United States
Louisville, Kentucky, United States
Milan, , Italy
Tucson, Arizona, United States
Barcelona, , Spain
Durham, North Carolina, United States
Madrid, , Spain
Tampa, Florida, United States
Fairfax, Virginia, United States
Nashville, Tennessee, United States
Ottawa, Ontario, Canada
Hasselt, , Belgium
Genova, , Italy
Varese, , Italy
Madrid, , Spain
Baltimore, Maryland, United States
Santiago De Compostela, , Spain
Osaka, , Japan
Seoul, , Korea, Republic Of
Madrid, , Spain
Taichung, , Taiwan
Baltimore, Maryland, United States
Long Beach, California, United States
Bay Pines, Florida, United States
Beer Sheva, , Israel
Orlando, Florida, United States
Chicago, Illinois, United States
Boston, Massachusetts, United States
Woolloongabba, Queensland, Australia
Frankfurt, , Germany
Park Ridge, Illinois, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Los Alamitos, California, United States
Albany, New York, United States
Edmonton, Alberta, Canada
Vancouver, British Columbia, Canada
Napoli, , Italy
Roma, , Italy
Bronx, New York, United States
Barcelona, , Spain
Kassel, , Germany
Vienna, , Austria
Bari, , Italy
Lublin, , Poland
Goshen, Indiana, United States
San Francisco, California, United States
Hemer, , Germany
Rotterdam, , Netherlands
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Covington, Louisiana, United States
Hackensack, New Jersey, United States
Germantown, Tennessee, United States
Dallas, Texas, United States
Ottawa, Ontario, Canada
Toronto, Ontario, Canada
Harderwijk, , Netherlands
Otwock, , Poland
Edegem, , Belgium
Sendai, Miyagi, Japan
Pensacola, Florida, United States
Omaha, Nebraska, United States
Tallahassee, Florida, United States
Eugene, Oregon, United States
Woolloongabba, , Australia
Athens, Georgia, United States
Hemer, , Germany
Torokbalint, , Hungary
Manchester, , United Kingdom
Tampa, Florida, United States
Seoul, , Korea, Republic Of
Tucson, Arizona, United States
Norwich, Connecticut, United States
Arlington, Texas, United States
Lexington, Kentucky, United States
Oldenburg, , Germany
Leicester, , United Kingdom
Columbus, Ohio, United States
San Francisco, California, United States
Chengdu, Sichuan, China
Roma, , Italy
Miami, Florida, United States
Austin, Texas, United States
Valencia, , Spain
Tyler, Texas, United States
Chemnitz, , Germany
Budapest, , Hungary
Esslingen, , Germany
Kashihara, Nara, Japan
Cleveland, Ohio, United States
Madrid, , Spain
Málaga, , Spain
Valencia, , Spain
Gent, , Belgium
Bedford Park, , Australia
Utrecht, , Netherlands
London, , United Kingdom
West Palm Beach, Florida, United States
Amarillo, Texas, United States
Jerusalem, , Israel
Toronto, Ontario, Canada
Hangzhou, Zhejiang, China
San Francisco, California, United States
Sevilla, , Spain
Vancouver, British Columbia, Canada
Fort Myers, Florida, United States
Santa Rosa, California, United States
Sioux Falls, South Dakota, United States
Bedford, Texas, United States
The Woodlands, Texas, United States
Hackensack, New Jersey, United States
Oldenburg, , Germany
Bologna, , Italy
Ballarat, Victoria, Australia
Dublin, , Ireland
Porto, , Portugal
Seoul, , Korea, Republic Of
A Coruna, , Spain
Jacksonville, Florida, United States
Valencia, , Spain
Wollongong, New South Wales, Australia
Jackson, Mississippi, United States
Teaneck, New Jersey, United States
Goyang Si, , Korea, Republic Of
Seoul, , Korea, Republic Of
Niles, Illinois, United States
Las Vegas, Nevada, United States
Suwon Si, , Korea, Republic Of
Frankfurt Am Main, , Germany
Roma, , Italy
Anaheim, California, United States
Sagamihara, Kanagawa, Japan
Barcelona, , Spain
Sevilla, , Spain
Jacksonville, Florida, United States
Kettering, Ohio, United States
Gießen, , Germany
Jerusalem, , Israel
Busan, , Korea, Republic Of
Beijing, Beijing, China
Rehovot, , Israel
Taipei City, , Taiwan
Taoyuan, , Taiwan
Taipei City, , Taiwan
San Francisco, California, United States
Barcelona, , Spain
Nanchang, Jiangxi, China
Columbus, Georgia, United States
Napoli, , Italy
Parma, , Italy
Valencia, , Spain
Leicester, , United Kingdom
Madrid, , Spain
Tel Aviv, , Israel
Parma, , Italy
Skorzewo, , Poland
Chengdu, Sichuan, China
Guangzhou, Guangdong, China
Jinan, Shandong, China
Whittier, California, United States
Linz, , Austria
Lone Tree, Colorado, United States
Toruń, , Poland
Hasselt, , Belgium
Gyöngyös, , Hungary
Cheongju Si, , Korea, Republic Of
Santiago De Compostela, , Spain
Daegu, , Korea, Republic Of
Cheongju Si, , Korea, Republic Of
Olomouc, , Czechia
Linz, , Austria
Meldola, , Italy
Olomouc, , Czechia
Torun, , Poland
East Brunswick, New Jersey, United States
Gdańsk, , Poland
Busan, , Korea, Republic Of
Daegu, , Korea, Republic Of
Tainan City, , Taiwan
Offenbach, , Germany
Nijmegen, , Netherlands
Springdale, Arkansas, United States
Bedford Park, , Australia
Lublin, , Poland
Haifa, , Israel
Richmond, Indiana, United States
Barcelona, , Spain
Otwock, , Poland
Rome, , Italy
Firenze, , Italy
Budapest, , Hungary
Afula, , Israel
Surrey, , United Kingdom
Galway, , Ireland
Kassel, Hessen, Germany
Suwon Si, Gyeonggi Do, Korea, Republic Of
Springdale, Arkansas, United States
Denison, Texas, United States
Fuzhou, Fujian, China
Roma, , Italy
London, , United Kingdom
Busan Si, , Korea, Republic Of
Kielce, , Poland
Salem, Oregon, United States
Sofia, , Bulgaria
Ostrava, , Czechia
Busan, , Korea, Republic Of
Waterford, , Ireland
Fairfax, Virginia, United States
Albany, New York, United States
West Palm Beach, Florida, United States
Lubeck, , Germany
London, , United Kingdom
Milano, , Italy
Lisbon, , Portugal
Garran, , Australia
Covington, Louisiana, United States
Madrid, , Spain
Jerusalem, , Israel
Afula, , Israel
Sakai Shi, Osaka, Japan
Tigard, Oregon, United States
Brescia, , Italy
Taizhou, Zhejiang, China
Olsztyn, , Poland
Bari, , Italy
Budapest, , Hungary
Milan, , Italy
Utrecht, , Netherlands
Prescott Valley, Arizona, United States
Stockton, California, United States
Goshen, Indiana, United States
Wichita, Kansas, United States
Salem, Oregon, United States
Meldola, Forli Cesena, Italy
Amsterdam, Noord Holland, Netherlands
Rotterdam, Zuid Holland, Netherlands
L'hospitalet De Llobregat, Barcelona, Spain
A Coruña, La Coruña, Spain
Edegem, Antwerpen, Belgium
Manchester, England, United Kingdom
Aventura, Florida, United States
Urumqi, Xinjiang, China
Poznan, , Poland
Burnsville, Minnesota, United States
Hořovice, Central Bohemian, Czechia
Incheon, Gyeonggi Do, Korea, Republic Of
Gent, Vlaams Brabant, Belgium
Esslingen, Baden Wuerttemberg, Germany
Großhansdorf, Schleswig Holstein, Germany
Birmingham, , United Kingdom
Porto, , Portugal
Merriam, Kansas, United States
Fredericksburg, Texas, United States
Praha, , Czechia
Fort Myers, Florida, United States
Fukushima Shi, , Japan
Safed, , Israel
London, England, United Kingdom
Pittsburgh, Pennsylvania, United States
Richmond, Virginia, United States
Vancouver, Washington, United States
Omaha, Nebraska, United States
Milan, , Italy
Be'er Sheva, , Israel
Reẖovot, , Israel
Lisbon, , Portugal
Munchen, Bayern, Germany
Lübeck, Schleswig Holstein, Germany
A Coruña, , Spain
Niles, Illinois, United States
Iwakuni, , Japan
Kempten, Bavaria, Germany
Surrey, England, United Kingdom
Krakow, , Poland
Methuen, Massachusetts, United States
Izmir, , Turkey
Farkasgyepu, , Hungary
Klagenfurt, Carinthia, Austria
Birmingham, England, United Kingdom
Bologna, , Italy
Gyongyos, , Hungary
Nashville, Tennessee, United States
Genova, , Italy
Athens, Georgia, United States
Guildford, England, United Kingdom
Dallas, Texas, United States
Torokbalint, , Hungary
Los Alamitos, California, United States
Marietta, Georgia, United States
Kettering, Ohio, United States
Denison, Texas, United States
Wichita, Kansas, United States
Prescott Valley, Arizona, United States
Anaheim, California, United States
Cerritos, California, United States
Long Beach, California, United States
Los Angeles, California, United States
Rancho Mirage, California, United States
Santa Rosa, California, United States
Stockton, California, United States
Lone Tree, Colorado, United States
Washington, District Of Columbia, United States
Bay Pines, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Miami, Florida, United States
Pensacola, Florida, United States
Tallahassee, Florida, United States
Tampa, Florida, United States
Weston, Florida, United States
Atlanta, Georgia, United States
Marietta, Georgia, United States
Honolulu, Hawaii, United States
Honolulu, Hawaii, United States
Chicago, Illinois, United States
Maywood, Illinois, United States
Park Ridge, Illinois, United States
Peoria, Illinois, United States
Westwood, Kansas, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
Baton Rouge, Louisiana, United States
Burnsville, Minnesota, United States
Minneapolis, Minnesota, United States
Minneapolis, Minnesota, United States
Rochester, Minnesota, United States
Jackson, Mississippi, United States
Las Vegas, Nevada, United States
Belleville, New Jersey, United States
East Brunswick, New Jersey, United States
Teaneck, New Jersey, United States
Rhinebeck, New York, United States
Cincinnati, Ohio, United States
Eugene, Oregon, United States
Allentown, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Providence, Rhode Island, United States
Charleston, South Carolina, United States
Spartanburg, South Carolina, United States
Germantown, Tennessee, United States
Austin, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Fredericksburg, Texas, United States
Houston, Texas, United States
Irving, Texas, United States
Odessa, Texas, United States
The Woodlands, Texas, United States
Salt Lake City, Utah, United States
Huntington, West Virginia, United States
Madison, Wisconsin, United States
Madison, Wisconsin, United States
Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Buenos Aires, , Argentina
Porto Alegre, , Argentina
Rio Cuarto, , Argentina
Ballarat, , Australia
Clayton, , Australia
Garran, , Australia
Wollongong, , Australia
Klagenfurt Am Woerthersee, , Austria
Wien, , Austria
Roeselare, , Belgium
Lajeado, Rio Grande Do Sul, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Barretos, , Brazil
Ijui, , Brazil
Rio De Janeiro, , Brazil
Sao Jose Do Rio Preto, , Brazil
Sao Paolo, , Brazil
Gabrovo, , Bulgaria
Haskovo, , Bulgaria
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Vratsa, , Bulgaria
Vancouver, British Columbia, Canada
London, Ontario, Canada
Montreal, Quebec, Canada
Santiago, , Chile
Temuco, , Chile
Medellin, , Colombia
Monteria, , Colombia
Horovice, , Czechia
Ostrava, , Czechia
Praha 2, , Czechia
Praha 8 Liben, , Czechia
Brest, , France
Creteil, , France
La Tronche, , France
Marseille, , France
Montpellier, , France
Mulhouse, , France
Paris Cedex 05, , France
Saint Herblain, , France
Strasbourg Cedex, , France
Tours Cedex 9, , France
Villejuif, , France
Batumi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Chemnitz, , Germany
Giessen, , Germany
Grohansdorf, , Germany
Heidelberg, , Germany
Heilbronn, , Germany
Jena, , Germany
Kempten, , Germany
Mainz, , Germany
Munchen, , Germany
Athens, , Greece
Athens, , Greece
Heraklion, , Greece
Larissa, , Greece
Peiraias, , Greece
Budapest, , Hungary
Farkasgyepu, , Hungary
Tatabanya, , Hungary
Cork, , Ireland
Dublin, , Ireland
Dublin, , Ireland
Dublin, , Ireland
Galway, , Ireland
Limerick, , Ireland
Waterford, , Ireland
Bat Galim, , Israel
Holon, , Israel
Tel Aviv, , Israel
Zsfat, , Israel
Aviano, , Italy
Brescia, , Italy
Candiolo, , Italy
Firenze, , Italy
Meldola, , Italy
Milano, , Italy
Monza, , Italy
Padova, , Italy
Perugia, , Italy
Pesaro, , Italy
Ravenna, , Italy
Rozzano, , Italy
Goyang Si, , Korea, Republic Of
Jung Gu, , Korea, Republic Of
Seoul, , Korea, Republic Of
Suwon Si, , Korea, Republic Of
Johor Bahru, Johor, Malaysia
George Town, Penang, Malaysia
Petaling Jaya, Selangor, Malaysia
Kuala Lumpur, , Malaysia
Mexico, Distrito Federal, Mexico
Mexico, Distrito Federal, Mexico
Guadalajara, Jalisco, Mexico
Monterrey, , Mexico
Monterrey, , Mexico
Amsterdam, , Netherlands
Den Haag, , Netherlands
Dordrecht, , Netherlands
Harderwijk, , Netherlands
Nijmegen, , Netherlands
Rotterdam, , Netherlands
Zwolle, , Netherlands
Trujillo, La Libertad, Peru
Cercado De Lima, Lima, Peru
Jesus Maria, Lima, Peru
Miraflores, Lima, Peru
San Isidro, Lima, Peru
San Isidro, Lima, Peru
Surquillo, Lima, Peru
Arequipa, , Peru
Arequipa, , Peru
Arequipa, , Peru
Cusco, , Peru
Lima, , Peru
Gdansk, , Poland
Kielce, , Poland
Krakow, , Poland
Lublin, , Poland
Olsztyn, , Poland
Poznan, , Poland
Skorzewo, , Poland
Warszawa, , Poland
Warszawa, , Poland
Coimbra, , Portugal
Guimaraes, , Portugal
Lisbon, , Portugal
Porto, , Portugal
Porto, , Portugal
Porto, , Portugal
Vila Nova De Gaia, , Portugal
Cluj Napoca, , Romania
Timișoara, , Romania
Singapore, , Singapore
Badalona, , Spain
Bilbao, , Spain
Burgos, , Spain
Jerez De La Frontera, , Spain
Las Palmas De Gran Canaria, , Spain
Leon, , Spain
Lhospitalet De Llobregat, , Spain
Malaga, , Spain
Santander, , Spain
Gavle, , Sweden
Taichung City, , Taiwan
Taichung, , Taiwan
Taichung, , Taiwan
Tainan City, , Taiwan
Tainan, , Taiwan
Taipei City, , Taiwan
Taipei City, , Taiwan
Taoyuan, , Taiwan
Alanya, , Turkey
Altindag, , Turkey
Ankara, , Turkey
Antalya, , Turkey
Bahcelievler, , Turkey
Bornova, , Turkey
Cankaya, , Turkey
Edirne, , Turkey
Istanbul, , Turkey
Izmir, , Turkey
Kocaeli, , Turkey
Malatya, , Turkey
Mamak, , Turkey
Sisli, , Turkey
Birmingham, , United Kingdom
Edinburgh, , United Kingdom
Kent, , United Kingdom
London, , United Kingdom
Giessen, , Germany
Dublin, , Ireland
Perugia, , Italy
Coimbra, , Portugal
Guimaraes, , Portugal
Badalona, , Spain
Goodyear, Arizona, United States
Safford, Arizona, United States
Safford, Arizona, United States
Safford, Arizona, United States
Safford, Arizona, United States
Safford, Arizona, United States
Fountain Valley, California, United States
Laguna Hills, California, United States
Long Beach, California, United States
Santa Ana, California, United States
Whittier, California, United States
Aurora, Colorado, United States
Boulder, Colorado, United States
Centennial, Colorado, United States
Colorado Springs, Colorado, United States
Colorado Springs, Colorado, United States
Denver, Colorado, United States
Denver, Colorado, United States
Lakewood, Colorado, United States
Littleton, Colorado, United States
Longmont, Colorado, United States
Pueblo, Colorado, United States
Thornton, Colorado, United States
Bonita Springs, Florida, United States
Bradenton, Florida, United States
Cape Coral, Florida, United States
Celebration, Florida, United States
Daytona Beach, Florida, United States
Fleming Island, Florida, United States
Fort Myers, Florida, United States
Fort Myers, Florida, United States
Jacksonville Beach, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Naples, Florida, United States
Naples, Florida, United States
Port Charlotte, Florida, United States
Saint Augustine, Florida, United States
Sarasota, Florida, United States
Sarasota, Florida, United States
Stuart, Florida, United States
Tallahassee, Florida, United States
Venice, Florida, United States
Venice, Florida, United States
Vero Beach, Florida, United States
Wellington, Florida, United States
Carrollton, Georgia, United States
Cartersville, Georgia, United States
Douglasville, Georgia, United States
Hiram, Georgia, United States
Arlington Heights, Illinois, United States
Chanute, Kansas, United States
El Dorado, Kansas, United States
Independence, Kansas, United States
Kingman, Kansas, United States
Liberal, Kansas, United States
Mcpherson, Kansas, United States
Newton, Kansas, United States
Parsons, Kansas, United States
Pratt, Kansas, United States
Salina, Kansas, United States
Wellington, Kansas, United States
Wichita, Kansas, United States
Winfield, Kansas, United States
Louisville, Kentucky, United States
Covington, Louisiana, United States
Covington, Louisiana, United States
Edina, Minnesota, United States
Grand Island, Nebraska, United States
Omaha, Nebraska, United States
Omaha, Nebraska, United States
Papillion, Nebraska, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Somerset, New Jersey, United States
Somerset, New Jersey, United States
Somerset, New Jersey, United States
Somerset, New Jersey, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Fairfield, Ohio, United States
Portland, Oregon, United States
Portland, Oregon, United States
Tigard, Oregon, United States
Dickson, Tennessee, United States
Franklin, Tennessee, United States
Gallatin, Tennessee, United States
Hendersonville, Tennessee, United States
Hermitage, Tennessee, United States
Lebanon, Tennessee, United States
Murfreesboro, Tennessee, United States
Nashville, Tennessee, United States
Nashville, Tennessee, United States
Nashville, Tennessee, United States
Nashville, Tennessee, United States
Shelbyville, Tennessee, United States
Smyrna, Tennessee, United States
Abilene, Texas, United States
Amarillo, Texas, United States
Arlington, Texas, United States
Arlington, Texas, United States
Austin, Texas, United States
Austin, Texas, United States
Bedford, Texas, United States
El Paso, Texas, United States
El Paso, Texas, United States
El Paso, Texas, United States
Longview, Texas, United States
Midland, Texas, United States
Tyler, Texas, United States
Wichita Falls, Texas, United States
Alexandria, Virginia, United States
Arlington, Virginia, United States
Gainesville, Virginia, United States
Leesburg, Virginia, United States
Immenstadt, Bayern, Germany
Roma, , Italy
Lisboa, , Portugal
Timisoara, , Romania
Pamplona, Navarre, Spain
Gabrovo, , Bulgaria
Haskovo, , Bulgaria
Plovdiv, , Bulgaria
Vratsa, , Bulgaria
Haskovo, , Bulgaria
Pula, , Croatia
Rijeka, , Croatia
Odense, , Denmark
Soenderborg, , Denmark
Tampere, , Finland
Chai Wan, , Hong Kong
Hong Kong, , Hong Kong
Kowloon, , Hong Kong
Oslo, , Norway
Port Elizabeth, Eastern Cape, South Africa
Johannesburg, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Sankt Gallen, , Switzerland
Villars Sur Glane, , Switzerland
Quezon City, , Philippines
Beograd, , Serbia
Zagreb, , Croatia
Vejle, , Denmark
Patna, , India
Bacolod City, , Philippines
Krung Thep Maha Nakhon, , Thailand
Mangalore, , India
Mysore, , India
Fukushima Shi, , Japan
Osaka, , Japan
Belgrade, , Serbia
Rajkot, , India
Molo, , Philippines
Sremska Kamenica, , Serbia
Makati City, , Philippines
Athens, Attiki, Greece
Sagamihara, Kanagawa, Japan
Sakai Shi, Osaka, Japan
Foxboro, Massachusetts, United States
Ahemdabad, , India
Aurangabad, , India
Hyderabad, , India
Hyderabad, , India
Kochi, , India
New Delhi, , India
Pesaro, , Italy
Akashi City, Hyogo, Japan
Sendai, Miyagi, Japan
Nagoya, , Japan
Nagoya, , Japan
Drammen, , Norway
Iloilo City, , Philippines
Floresti, , Romania
Ankara, , Turkey
Merriam, Kansas, United States
Brighton, Massachusetts, United States
Milford, Massachusetts, United States
Koln, , Germany
Ahmedabad, , India
Belagavi, , India
Jaipur, , India
Kolkata, , India
Madurai, , India
Pune, , India
Toon Shi, Ehime, Japan
Kashihara, Nara, Japan
Iwakuni, , Japan
Osaka, , Japan
Toyama, , Japan
Seoul, , Korea, Republic Of
George Town, Penang, Malaysia
Cebu City, , Philippines
Kragujevac, , Serbia
Uzice, , Serbia
Taipei City, , Taiwan
Bangkok, , Thailand
Austin, Texas, United States
Odessa, Texas, United States
New Delhi, , India
Suwon Si, , Korea, Republic Of
Cerritos, California, United States
South Weymouth, Massachusetts, United States
Angers Cedex 02, , France
Boulogne Billancourt, , France
Caen Cedex 5, , France
Limoges Cedex, , France
Marseille, , France
Rennes Cedex 9, , France
Saint Herblain, , France
Mumbai, , India
Varanasi, , India
Nagasaki Shi, Nagasaki, Japan
Nankoku Shi, , Japan
Kuala Lumpur, , Malaysia
Wuhan, Hubei, China
Bengbu, Anhui, China
Hefei, Anhui, China
Hefei, Anhui, China
Hefei, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Xiamen, Fujian, China
Xiamen, Fujian, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Liuzhou, Guangxi, China
Nanning, Guangxi, China
Nanning, Guangxi, China
Shijiazhuang, Hebei, China
Harbin, Heilongjiang, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Wuhan, Hubei, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nantong, Jiangsu, China
Xuzhou, Jiangsu, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Yinchuan, Ningxia, China
Xi'an, Shaanxi, China
Linyi, Shandong, China
Qingdao, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Taiyuan, Shanxi, China
Taiyuan, Shanxi, China
Chengdu, Sichuan, China
Luzhou, Sichuan, China
Urumchi, Xinjiang, China
Urumqi, Xinjiang, China
Kunming, Yunnan, China
Kunming, Yunnan, China
Kunming, Yunnan, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Taizhou, Zhejiang, China
Shanghai, , China
Lowenstein, , Germany
Neuruppin, , Germany
Bangalore, , India
Jaipur, , India
Palmerston North, , New Zealand
Bengbu, Anhui, China
Hefei, Anhui, China
Hefei, Anhui, China
Hefei, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Fuzhou, Fujian, China
Xiamen, Fujian, China
Xiamen, Fujian, China
Xiamen, Fujian, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Liuzhou, Guangxi, China
Nanning, Guangxi, China
Nanning, Guangxi, China
Nanning, Guangxi, China
Shijiazhuang, Hebei, China
Harbin, Heilongjiang, China
Harbin, Heilongjiang, China
Xinxiang, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Zhengzhou, Henan, China
Wuhan, Hubei, China
Wuhan, Hubei, China
Wuhan, Hubei, China
Changsha, Hunan, China
Changsha, Hunan, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nanjing, Jiangsu, China
Nantong, Jiangsu, China
Xuzhou, Jiangsu, China
Nanchang, Jiangxi, China
Nanchang, Jiangxi, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Changchun, Jilin, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Shenyang, Liaoning, China
Yinchuan, Ningxia, China
Xi'an, Shaanxi, China
Xi'an, Shaanxi, China
Xi'an, Shaanxi, China
Jinan, Shandong, China
Jinan, Shandong, China
Linyi, Shandong, China
Linyi, Shandong, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Taiyuan, Shanxi, China
Taiyuan, Shanxi, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Luzhou, Sichuan, China
Urumchi, Xinjiang, China
Urumchi, Xinjiang, China
Kunming, Yunnan, China
Kunming, Yunnan, China
Kunming, Yunnan, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Hangzhou, Zhejiang, China
Taizhou, Zhejiang, China
Taizhou, Zhejiang, China
Qingdao, , China
Qingdao, , China
Macon, Georgia, United States
Port Macquarie, , Australia
Amberg, , Germany
Monchengladbach, , Germany
Harderwijk, , Netherlands
Bahcelievler, , Turkey
Edirne, , Turkey
Istanbul, , Turkey
Merriam, Kansas, United States
Belgrano, Buenos Aires, Argentina
Rosario, Santa Fe, Argentina
Hyde Park, , Australia
Natal, Rio Grande Do Norte, Brazil
Helsinki, , Finland
Augsburg, , Germany
Chemnitz, , Germany
Hamburg, , Germany
Ulm, , Germany
Nagoya, , Japan
Nagoya, , Japan
Floreti, , Romania
Timioara, , Romania
Los Alamitos, California, United States
Bengbu, Anhui, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Fuzhou, Fujian, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Shenzhen, Guangdong, China
Nanning, Guangxi, China
Changsha, Hunan, China
Nanjing, Jiangsu, China
Nanchang, Jiangxi, China
Changchun, Jilin, China
Shenyang, Liaoning, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Hangzhou, Zhejiang, China
Tbilisi, , Georgia
Lublin, , Poland
Nishinomiya Shi, Hyogo, Japan
Malatya, , Turkey
Kanazawa, , Japan
Palmerston North, , New Zealand
Mamak, , Turkey
Chongqing, Chongqing, China
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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