Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Launched by EUROPEAN FOUNDATION FOR STUDY OF CHRONIC LIVER FAILURE · Oct 28, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the use of liver transplantation in patients who have severe liver conditions, specifically those with liver cirrhosis and acute-on-chronic liver failure (ACLF). Researchers are looking to understand when liver transplantation might be the best option for these patients and what outcomes they can expect after the surgery. The trial is open to both men and women aged 18 and older who are experiencing severe liver issues and have been hospitalized for their condition. Participants may be listed for a liver transplant, may have poor liver function without ACLF, or may be evaluated but not listed for a transplant.

If you or a loved one are eligible and choose to participate, you will receive close monitoring and care from a transplant team. The goal of the study is to find ways to improve survival rates and outcomes for patients undergoing liver transplantation, especially since there are not enough donor organs available. It's important to discuss any questions or concerns with your healthcare provider to understand how this trial might fit into your or your loved one’s care plan.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female subject ≥18 years of age.
• • 2. Subjects with diagnosis of liver cirrhosis (based on clinical, laboratory, endoscopic, and ultrasonographic features or on histology).
• 3. Subjects who have been hospitalized for acute decompensation of liver cirrhosis and referred to the transplant team:
• • Group 1: patients listed for liver transplantation with ACLF-2 or 3 at the time of listing or developing ACLF 2-3 while on the waiting list.
• • Group 2: patients listed for liver transplantation with decompensated cirrhosis without ACLF-2 or 3 and poor liver function (MELD\>20) at the time of listing.
• • Group 3: patients having ACLF-2 or 3, are assessed for inclusion in the waiting list, but are finally not listed for liver transplantation.
• • 4. Patients (or trusted person, family member or close relation if the patient is unable to express consent) who have been informed and signed their informed consent Inclusion criteria
• Exclusion Criteria:
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