London Underground Study - Health Effects of Particulate Matter

Launched by IMPERIAL COLLEGE LONDON · Oct 28, 2020

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

• Inclusion Criteria for both groups:
• • Give informed consent
• • London resident
• For participants with COPD:
• • GOLD stage 2 COPD (FEV1/FVC\<70%; 50%\>FEV1\<80% predicted), GOLD stage 3 COPD (FEV1/FVC\<70%; 30%\>FEV1\<50%) and GOLD stage 4 (FEV1/FVC\<70%;FEV1\<30%)
• • No history of ischaemic heart disease
• For healthy volunteers:
• • No history of ischaemic heart disease.
• • Normal lung function with no evidence of airflow obstruction.
• Exclusion Criteria for both participants with COPD and healthy volunteers:
• • Those with unstable ischaemic heart disease or COPD.
• • Current smokers and those who are ex-smokers of \<12 months duration.
• • Those who work in the London Underground or are occupationally exposed to - - high levels of vehicle traffic exposure on a frequent basis.
• • Those who cannot walk for 30 mins.
• • Involvement in another research study
• • Those unable to give consent.