Immunological Mechanisms of Rejection in Uterine Transplantation

Launched by HOPITAL FOCH · Nov 2, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how the body reacts to uterine transplants, specifically focusing on understanding why some transplants are rejected. Researchers want to find out if there are simple tests that can help identify signs of rejection without needing invasive procedures. To gather information, they will collect biological samples like blood and tissue during regular follow-up appointments, which means patients won’t have to undergo extra procedures just for the study.

Women who are eligible to participate include those who are either planning to receive a uterine transplant or have already had one, as well as those who have donated a uterus. There are specific age requirements: participants must be between 18 and 45 years old, depending on their situation. It’s important to note that certain medical conditions, like pregnancy, infections, or a history of cancer, may prevent someone from joining the study. If you decide to participate, you can expect to contribute to valuable research that could improve future uterine transplant outcomes while being supported throughout the process.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patient going to or having received a uterine transplant OR Patient going to or having donated a uterus for a recipient included in the study OR Premenopausal woman to undergo gynecological surgery under general anesthesia: for 4 of them it was a hysterectomy and they must be under 45 years old, the other 6 must be under 38 years old.
• Exclusion Criteria (For witness):
• • Pregnancy in progress
• • Current infection
• • Cervical dysplasia
• • History of transplant or transfusion
• • Cancer or history of cancer
• • Menopause
• • Patient aged 38 or over for the 6 controls without hysterectomy, patient aged 45 or over for the 4 patients with hysterectomy.
• • Endometriosis