Genetic Investigation of Cancer Predisposition

Launched by THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO · Nov 5, 2020

Keywords

ClinConnect Summary

This clinical trial, titled "Genetic Investigation of Cancer Predisposition," is looking into how certain genetic factors might increase the risk of developing cancer. Researchers want to collect blood, saliva, and tumor samples from patients who have had various types of cancer, especially those diagnosed before the age of 50 or those with a family history of cancer. They will also include family members, whether they are affected by cancer or not, to help identify specific genetic changes that may contribute to cancer risk.

To be eligible for this trial, participants can be of any age and should meet at least one of several criteria, such as having a personal history of cancer at a young age, having multiple cancers, or having a family history of cancer that doesn’t fit typical hereditary patterns. Participants will be asked to provide detailed medical records and family history regarding cancer. While the trial is not yet recruiting, it is an important step toward understanding genetic risks associated with cancer, which could ultimately lead to better prevention and treatment options.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Any age
• 2. Meets at least ONE of the following:
• • 1. Personal history (with documented diagnosis) of cancer before the age of 50
• • 2. Personal history of more than one primary cancer
• • 3. Documented diagnosis of cancer AND family history of that same cancer type or multiple other cancers that do not fit classical criteria of hereditary cancer syndromes
• • 4. Documented diagnosis of a rare cancer AND family history of rare cancers that do not fit classical criteria of hereditary cancer syndromes
• • 5. There is the same type of cancer in several generations of a family
• • 6. Documented diagnosis of multicentric cancers (e.g bilateral cancers in paired organs, or multifocal cancers in single organs) that usually occur as single lesions when presented sporadically
• • 7. Early onset cancer (before the age of 50, or breast cancer before age 45) AND family history of early onset cancer Capable of providing access to detailed medical records and family history of cancer
• Exclusion Criteria:
• • 1. Established genetic diagnosis of a known hereditary cancer syndrome that is compatible with the clinical presentation
• • 2. Incarcerated