An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Nov 4, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how different types of kidney cancers, including various forms of renal cell carcinoma and urothelial carcinoma, use nutrients from the body to grow. Researchers want to learn more about how these tumors metabolize (or process) nutrients like glucose and glutamine, which come from the foods we eat. To do this, participants will receive a special nutrient tracer through an IV during their surgery or biopsy. This will help the team monitor how the tumors use these nutrients, and they will also collect tissue samples from the tumors for analysis.

To be eligible for this study, participants must be 18 years or older and have imaging that shows they have kidney or urothelial cancer that needs surgery or a biopsy. It’s important to note that participating in this study won’t change the standard treatment patients receive; everyone will continue to get the usual care as determined by their doctors. The trial is currently recruiting patients, and those interested might want to discuss it with their healthcare provider to see if it’s a good fit for them.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients must have radiographic evidence of known or probable kidney or urothelial cancer requiring surgical biopsy or excision.
• • Age ≥ 18 years
• • Subjects of all races and ethnic origins
• • The willingness to sign and ability to understand a written informed consent.
• • Patients participating in other clinical trials are eligible, and will be evaluated on a case by case basis by the Principal Investigator, Dr. Vitaly Margulis, MD.
• Exclusion Criteria:
• • Uncontrolled or poorly controlled diabetes for patients receiving a 13C infusion
• • Pregnant or breastfeeding
• • Not a surgical candidate