Transspinal-Transcortical Paired Stimulation for Neuroplasticity and Recovery After SCI
Launched by COLLEGE OF STATEN ISLAND, THE CITY UNIVERSITY OF NEW YORK · Nov 5, 2020
Trial Information
Current as of June 29, 2025
Completed
Keywords
ClinConnect Summary
Motor dysfunction after SCI results in substantial personal, social, and economic costs. Secondary complications related to muscle spasticity and motor dysfunction significantly reduce quality of life. Rehabilitation efforts are compromised because most therapeutic interventions rely heavily on sensory afferent feedback that is interpreted by malfunctioned neuronal networks. On the other hand, electrical signals delivered over the spine regenerate neurons of the spinal cord in injured animals, and paired associative stimulation produces enduring neuronal plasticity in healthy and injured hu...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Clinical diagnosis of motor incomplete spinal cord injury (SCI).
- • SCI is above thoracic 12 vertebra.
- • Absent permanent ankle joint contractures.
- • SCI occurred 6 months before enrollment to the study.
- Exclusion Criteria:
- • Supraspinal lesions
- • Neuropathies of the peripheral nervous system
- • Degenerative neurological disorders
- • Presence of pressure sores
- • Urinary tract infection
- • Neoplastic or vascular disorders of the spine or spinal cord
- • Pregnant women or women who suspect they may be or may become pregnant
- • People with cochlear implants, pacemaker, and implanted simulators
- • People with history of seizures
- • People with implanted Baclofen pump
About College Of Staten Island, The City University Of New York
The College of Staten Island, part of the City University of New York (CUNY), is a leading academic institution dedicated to advancing research and education in various fields, including health sciences. As a clinical trial sponsor, the College leverages its robust academic resources and a diverse pool of expertise to conduct innovative studies aimed at improving patient care and public health outcomes. The institution fosters collaborations among faculty, researchers, and healthcare professionals, ensuring the implementation of rigorous methodologies and adherence to ethical standards in clinical research. With a commitment to community engagement and scholarly excellence, the College of Staten Island plays a pivotal role in contributing to the body of knowledge that informs clinical practices and policies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Staten Island, New York, United States
Patients applied
Trial Officials
Maria Knikou, PT, PhD
Principal Investigator
College of Staten Island, City University of New York
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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