Genetic of Response to Acute Saline Load Test in Hypertension (Naload)

Launched by OSPEDALE SAN RAFFAELE · Nov 10, 2020

Keywords

ClinConnect Summary

The Naload trial is studying how different genetic factors might affect how patients with hypertension (high blood pressure) respond to a saline load test, which involves giving a salt solution to assess their body's reaction. Researchers aim to better understand the relationship between genetics and blood pressure responses, which may help in developing personalized treatments for hypertension.

To participate in this study, individuals aged 18 to 65 with a body mass index (BMI) under 30 and specific blood pressure measurements (systolic over 140 mm Hg and diastolic over 90 mm Hg) can be considered. Participants will need to provide urine and blood samples for various tests, including genetic testing and checks on kidney function and hormone levels. It’s important to note that some people, such as those with a history of serious heart issues, diabetes, or severe hypertension, will not be eligible for this trial. If you join, you will be contributing to important research that could lead to better understanding and treatment of high blood pressure in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age 18 to 65years;
• • body mass index (BMI) \<30 kg/m2;
• • Na intake, evaluated as urinary Na excretion of \<300 mEq/24 hours; .office systolic BP (SBP) \>140 mm Hg and diastolic BP (DBP) \>90 mm Hg in 3 consecutive visits to their family doctors.
• Exclusion criteria:
• • Female patients
• • history of myocardial infarction,
• • stroke,
• • congestive heart failure,
• • liver disease, secondary cause of hypertension,
• • diabetes,
• • severe hypertension (\>160/110 mm Hg),
• • abuse of drugs or alcohol, .creatinine clearance \< 80 mL/m.
• • Secondary forms of hypertension (e.g. primary aldosteronism) were ruled out with specific investigations when deemed appropriate