Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study

Launched by OHIO STATE UNIVERSITY · Nov 16, 2020

Keywords

ClinConnect Summary

The Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Study is a research project designed to learn more about dilated cardiomyopathy (DCM), a condition that affects the heart's ability to pump blood. This study specifically uses advanced imaging technology called cardiac magnetic resonance (CMR) to look for early signs of DCM in family members who may be at risk because of their relationship to someone already diagnosed with the condition. The study is currently looking for participants who are 18 years or older and have been linked to a participant in the main study, the DCM Precision Medicine Study. Eligible participants must not have certain heart conditions or major health issues that could interfere with the study.

If you or a family member is interested in participating, you can expect to visit one of the participating sites for testing. The main goal is to help researchers understand how DCM develops, particularly in families, which could lead to better prevention and treatment options in the future. It’s important to note that participants will need to provide consent and be willing to communicate in English. This study welcomes people from all backgrounds and does not require previous experience with medical studies. If you have questions about your eligibility or the study process, don't hesitate to reach out for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The FDR's proband was enrolled in the DCM Precision Medicine Study at 1 of 9 participating sites, or exceptions granted by study PI.
• • 2. The FDR's proband has had one or more variants identified, including P, LP and VUS.
• • 3. The FDR is able report to one of the participating sites for study enrollment.
• • 4. The FDR has no current contraindication for CMR (glomerular filtration rate (GFR) \<30 mL/min/1.73 m2, non-compatible device implant, or allergy to gadolinium contrast).
• • 5. The FDR has had no prior heart transplant.
• • 6. The FDR is ≥18 years of age.
• • 7. All races/ethnicity
• • 8. Ability to give informed consent.
• • 9. Ability to communicate in English.
• • 10. Subject is not pregnant (CMR may be conducted 3-6 months post delivery)
• • 11. Willingness to participate in a family-based study (subject willing to interact with OSU).
• Exclusion Criteria:
• • 1. Coronary artery disease (CAD) causing ischemic cardiomyopathy (\> 50% narrowing, any major epicardial coronary artery).
• • 2. Primary valvular disease.
• • 3. Adriamycin or other cardiotoxic drug exposure.
• • 4. Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.
• • 5. Congenital heart disease.
• • 6. Other detectable causes of dilated cardiomyopathy, including sarcoid and hemochromatosis.
• • 7. Other active multisystem disease, even if very rare, that may plausibly cause DCM (e.g., hypereosinophilic syndrome, cardiac involvement with connective tissue disease, Loeffler's endocarditis, endomyocardial fibrosis, etc) are excluded. Please call the PI to discuss if uncertain or not clear.
• • 8. Severe and untreated or untreatable hypertension (systolic blood pressures routinely greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if resistant to multidrug treatment). This includes profound hypertension associated with other multisystem disease (e.g., scleroderma, other vasculitides, etc).