Ex Vivo Test of New Stroke Treatment Using Magnetic Nanorobots

Launched by CHINESE UNIVERSITY OF HONG KONG · Nov 20, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for thrombosis, which is a condition where blood clots form and can block blood flow, leading to strokes. Researchers are testing a magnetic nanorobotic system that can deliver a drug called tPA directly to the blood clots. The goal is to make the treatment more effective and minimize damage to surrounding healthy tissues. To conduct this study, they will use human placenta as a model to mimic the human brain's blood vessels.

To participate in this trial, women who are healthy and pregnant, between the ages of 20 and 45, may be eligible. Participants must be planning to give birth naturally or via cesarean section, and they need to provide informed consent to join the study. Those with certain health conditions, such as diabetes, a history of stroke in the family, or any significant medical issues, will not be able to participate. If you join the study, you can expect to help researchers learn more about this innovative approach to treating strokes, which could lead to better outcomes for patients in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy pregnant women at 20-45 years of age of any ethic origin, giving childbirth with natural delivery or caesarean sections after 37-42 weeks of gestation.
• • Healthy singleton pregnancy.
• • Participant able to give voluntary, written, informed consent to participate in the study.
• Exclusion Criteria:
• • Abnormal prenatal development (e.g intrauterine growth restriction)
• • Early preterm birth \< 37 weeks
• • Verbal Confirmation of hypercholesterolemia
• • Family history of stroke or vascular disease
• • Type I or Type II diabetes and gestational diabetes
• • Cancer, except skin cancers completely excised with no chemotherapy or radiation with a follow up that is negative.
• • Clinically significant abnormal laboratory results at screening.
• • Any other active or unstable medical condition.
• • History of liver disease.
• • History of hypertension (including pre-eclampsia)