European Blood Pressure Intensive Control After Stroke

Launched by UNIVERSITY COLLEGE DUBLIN · Nov 27, 2020

Keywords

ClinConnect Summary

The European Blood Pressure Intensive Control After Stroke trial is studying how well home blood pressure monitoring and telemonitoring (which means checking your blood pressure remotely, often with the help of technology) work compared to regular doctor visits in managing high blood pressure after a stroke. High blood pressure is a major risk factor for future strokes and heart problems, so this study aims to see if improving blood pressure control at home can help keep patients healthier. Essentially, they want to find out if using technology and medication adjustments at home can lead to better outcomes for stroke survivors.

To be eligible for this study, participants should be at least 40 years old and have experienced an ischemic stroke or a high-risk transient ischemic attack (which is a temporary blockage of blood flow to the brain) within the last year. They should also have high blood pressure (at least 140mmHg) and be able to live independently, even if they need some help with daily activities. If you join the study, you can expect to monitor your blood pressure at home, receive support through telemonitoring, and have medication adjustments based on your readings. This trial is currently recruiting participants, and it's important to note that those with certain health issues or who are pregnant may not be eligible to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥40
• • 2. Ischaemic stroke1, high-risk TIA, proven by imaging (brain CT/MRI)
• • 3. Living at home and independent (walking without the aid of another person, but may have some help for daily activities)
• • 4. SBP≥140mmHg at entry (average of 2 measures, seated, in the same arm, after resting alone in office for 10 minutes)
• • 5. Qualifying event between 30 days and 1 year of randomisation
• • 6. Glomerular filtration rate (eGFR) greater than or equal to 50ml/min/m2 (within 3 months of randomisation)
• • 7. Medically-stable and capable of participating in a randomised trial, including home BP measures, in the opinion of the study physician
• • 8. Willing to provide informed consent (no surrogate consent will apply)
• Exclusion Criteria:
• • 1. SBP \<110mmHg after 3 minutes of standing or other contra-indication to intensive SBP lowering in opinion of treating clinician (eg. Orthostatic symptoms, syncope or pre syncope, recurrent falls)
• • 2. Qualifying stroke due to intracerebral haemorrhage (ICH), cardio-embolism or other defined causes (eg. dissection, endocarditis, other specified)
• • 3. Severe stenosis or occlusion of large cranio-cervical artery (\>70% stenosis/occlusion of cervical carotid, vertebral, or Circle of Willis artery)
• • 4. Unlikely to comply with study procedures due to severe or fatal comorbid illness (eg. dementia, active malignancy, severe frailty) or other factor (eg. inability to travel)
• • 5. Pregnancy or breastfeeding