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Search / Trial NCT04649034

Intraventricular Stasis In Cardiovascular Disease

Launched by HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON · Nov 24, 2020

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Cardiac Thrombosis Silent Brain Infarct Stroke Fluid Dynamics Intracardiac Blood Flow Echocardiography Phase Contrast Magnetic Resonance Imaging

ClinConnect Summary

This clinical trial, titled "Intraventricular Stasis In Cardiovascular Disease," is looking to understand how blood flow is affected in the heart for patients with certain heart conditions, such as dilated cardiomyopathy and hypertrophic cardiomyopathy. The researchers want to find out if there is a connection between blood flow issues and the risk of silent blood clots or strokes in these patients. To do this, they will use advanced imaging techniques to take detailed pictures of the heart and analyze the results.

To participate in this trial, individuals must be over 18 years old and have a specific type of heart condition that meets certain criteria, such as a weakened heart muscle with a low ejection fraction (which measures how well the heart pumps blood). Unfortunately, some people may not qualify, including those with certain heart devices, significant valve issues, or those who have had serious blood clotting problems. Participants in the trial can expect to undergo non-invasive imaging tests and will be contributing to important research that might help improve care for others with similar heart conditions.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients over 18 years of age.
  • Sinus rhythm.
  • * Meet one of the following criteria:
  • Diagnosis of non ischemic DCM and ejection fraction (EF) of LV less than 45%
  • Diagnosis of ischemic DCM and ejection fraction (EF) of LV less than 45%
  • Diagnosis of hypertrofic myocardiophathy and ejection fraction (EF) of LV less than 55% or apical aneurism diagnosed in an image test.
  • Exclusion Criteria:
  • Implantable defibrillation or stimulation devices not compatible with MRI.
  • Hemodinamically significant heart valve disease or prosthetic heart valves.
  • Claustrophobia.
  • Persistent of paroxysmal atrial fibrillation (AF).
  • Prior history of significant carotid disease with stenosis greater than 50%.
  • Full anticoagulation therapy prior to admission or indication of anticoagulation.
  • Pro-thrombotic disorders (active oncology disease, coagulation disorders...)

About Hospital General Universitario Gregorio Marañon

The Hospital General Universitario Gregorio Marañón is a leading healthcare institution located in Madrid, Spain, renowned for its commitment to clinical excellence and innovative research. As a prominent clinical trial sponsor, the hospital combines advanced medical practices with cutting-edge research methodologies to facilitate the development of new therapies and improve patient outcomes. With a multidisciplinary team of experts and state-of-the-art facilities, the hospital actively engages in a wide range of clinical trials, contributing to the advancement of medical knowledge and the enhancement of healthcare delivery both locally and globally.

Locations

Madrid, , Spain

Barcelona, , Spain

Salamanca, , Spain

Patients applied

0 patients applied

Trial Officials

Javier Bermejo Thomas, MD, PhD

Principal Investigator

Hospital General Universitario Gregorio Marañón

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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