Effect of Vitamin D on Ovulation Rate in Women With Polycystic Ovary Syndrome

Launched by THE UNIVERSITY OF HONG KONG · Nov 24, 2020

Keywords

ClinConnect Summary

This clinical trial is looking at how taking vitamin D might help women with Polycystic Ovary Syndrome (PCOS) who have irregular menstrual cycles and struggle with ovulation. The goal is to see if vitamin D can improve the chances of ovulating and also look at other health factors over the course of a year.

To participate, women need to be between 18 and 40 years old, premenopausal, and have been diagnosed with PCOS based on specific criteria. It's important that they have irregular menstrual cycles, meaning their cycles are longer than 35 days. Participants should not have used any hormonal medications in the last three months, and they should not have certain medical conditions or be on specific types of medications that could affect the study. If they join, participants can expect to receive either vitamin D or a placebo (a non-active substance) for a year, and they'll have regular check-ins, including ultrasounds, to monitor their progress.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Premenopausal
• • Aged 18-40 years
• • Irregular long menstrual cycles (\>35 days)
• • PCOS according to the Rotterdam criteria
• • Agree for transvaginal ultrasound
• Exclusion Criteria:
• • Use of hormonal medication (including contraception) within 3 months prior to study inclusion, except the use of a progestogen to induce withdrawal bleeding every 3 months
• • History of any medical condition or medications that may predispose to vitamin D sensitivity, altered vitamin D metabolism and/ or hypercalcemia, including active tuberculosis or current therapy for tuberculosis, sarcoidosis, history of renal/ ureteral stones, parathyroid disease, renal or liver failure or current use of anti-convulsants
• • Use of insulin-sensitizing drugs, lipid lowering drugs or anti-hypertensive
• • Anticipated to use the above medications in the coming one year
• • Known type 2 diabetes mellitus
• • Refusal to join the study
• • Abnormal blood calcium level
• • For those on supplements, we asked them to stop their own supplements.