Endoscopic Cyclophotocoagulation in Normal Tension Glaucoma

Launched by HELSINKI UNIVERSITY CENTRAL HOSPITAL · Nov 26, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for people with normal tension glaucoma, which is a type of eye condition where the pressure inside the eye is normal, but damage still occurs to the optic nerve. The researchers want to find out if a procedure called endoscopic cyclophotocoagulation, when added to cataract surgery, can help lower eye pressure more effectively than cataract surgery alone. This trial is currently looking for participants who have been diagnosed with normal tension glaucoma and have a significant cataract that needs to be treated.

To be eligible for the study, participants must be adults who can provide consent, have stable glaucoma that is being managed with medication, and show specific signs of nerve damage in their eye. However, people with certain other eye conditions or those who have had previous eye surgeries may not be eligible. If you join the trial, you can expect to receive the standard cataract surgery along with the new treatment to see if it improves your eye pressure better than just the surgery alone. This trial is important as it could lead to better treatment options for those with normal tension glaucoma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Signed Informed Consent
• • Normal Tension Glaucoma with typical nerve fiber layer defects in red-free photographs and/or optical coherence tomography (OCT) and possible equivalent visual field defects, IOP never more than 21 mmHg, and open anterior chamber angle
• • Glaucoma stable with current medication assessed by a glaucoma specialist
• • Clinically significant cataract
• Exclusion Criteria:
• • Secondary Glaucoma e.g. due to previous injury or uveitis
• • Exfoliation syndrome
• • Pigment dispersion syndrome
• • Previous transscleral or endoscopic cyclophotocoagulation
• • Previous other glaucoma surgery
• • Cataract due to eye injury or congenital cataract
• • Zonular weakness due to Marfan syndrome or other
• • Previous retinal detachment
• • Previous intraocular surgery like vitrectomy and other retinal surgery
• • Wet age-related macular degeneration
• • Diabetic retonopathy
• • Previous corneal transplant or previous refractive surgery
• • Fuchs' dystrophy and other abnormalities compromising corneal clarity like scars
• • The patient does not want to participate in the study
• • The glaucoma progresses on current IOP
• • The patient does not speak Finnish, Swedish or English
• • Dementia
• • Only eye with vision worse than 20/200 or loss of central visual field