Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients

Launched by INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, FRANCE · Nov 25, 2020

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how the brain behaves during epileptic seizures, specifically in patients with a type of epilepsy called focal epilepsy that doesn't respond to medication. Researchers will use special electrodes implanted in the brain to record brain activity. This will help them learn not only about seizures but also about other important brain functions, like sleep and thinking skills, while the patients are undergoing tests before possible surgery.

To be eligible for this study, patients must have focal drug-resistant epilepsy and will need to be evaluated with these electrodes at a specific hospital. They should be able to give their consent to participate, meaning they understand the study and agree to take part. However, some individuals won't be able to join, such as those with certain medical conditions, pregnant or breastfeeding women, and minors. This study is still in the planning stages and hasn’t started recruiting participants yet. If you or a loved one are considering this, it could provide valuable insights into epilepsy and how to better treat it.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with focal drug-resistant epilepsy
• • Patients who undergo a presurgical evaluation with intracranial electrodes in the videoEEG unit of the Neurology department at the Pitié-Salpêtrière hospital.
• • Patients who have been informed and provided written informed consent to take part in the study
• Exclusion Criteria:
• • Contraindication for an intracranial investigation (with macro-electrodes) : intercurrent infectious syndrome, decompensated associated pathology (cardiac, pulmonary, renal, hepatic), patient with increased risk of infection (ex: under immunosuppressive therapy)
• • Pregnant or parturient woman
• • Breastfeeding woman
• • Minor person or legally protected adult (tutelage, legal guardianship, maintenance of justice)