Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU

Launched by KU LEUVEN · Dec 1, 2020

Keywords

ClinConnect Summary

This clinical trial is studying how different types of respiratory muscle training can help patients who are having trouble coming off mechanical ventilation in the ICU. Mechanical ventilation is a machine that helps patients breathe when they are too weak to do it on their own, but it can sometimes cause weakness in the muscles that control breathing. This trial aims to understand how these muscles respond to various training methods during the weaning process, which is the time when patients are gradually taken off the ventilator.

To participate in this study, patients need to be between the ages of 65 and 74 and have had difficulty coming off mechanical ventilation. They should be stable in their health, meaning their temperature and blood pressure are normal, and they don't have serious heart issues or other significant health problems. Participants will be monitored while they try different training approaches that may help strengthen their breathing muscles. This research is important because it could lead to better ways to help patients recover from mechanical ventilation and improve their chances of survival in the ICU.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Difficult and prolonged weaning patients
• • Adequate oxygenation
• • Febrile temperature \< 38ºC
• • Hemodynamic stability
• • Stable blood pressure
• • No or minimal vasopressors
• • No myocardial ischemia
• • Adequate hemoglobin and mentation
• • Resolution of disease acute phase
• • Able to follow simple verbal commands related to IMT
• • Mechanically ventilated via a tracheostomy or endotracheal tube
• Exclusion Criteria:
• • Pre-existing neuromuscular disease
• • Agitation
• • Hemodynamically instable (arrhythmia, decompensated heart failure, coronary insufficiency)
• • Hemoptysis
• • Diaphoresis
• • Spinal cord injury above T8
• • Use of any type of home MV support prior to hospitalization
• • Skeletal pathology that impairs chest wall movements
• • Poor general prognosis or fatal outcome