Can BCG Vaccination at First Health-facility Contact Reduce Early Infant Mortality?
Launched by BANDIM HEALTH PROJECT · Dec 1, 2020
Trial Information
Current as of July 22, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring whether giving the BCG vaccine, which helps protect against tuberculosis, more frequently at health facilities can reduce early infant deaths in Guinea-Bissau. Currently, BCG vaccination often happens only once a week if there are enough children present, which can lead to delays. The researchers believe that by making the vaccine available every day, even for just one baby, they can lower the risk of babies dying from non-accidental causes by 25%.
To participate in this study, babies born in three specific regions of Guinea-Bissau (Oio, Biombo, and Farim) and registered by health workers will be eligible, as long as they are not born outside these areas or die within the first day. If their mothers agree, the babies will be monitored until they are 42 days old, which is when they are scheduled for other vaccinations. The study will look at how many babies survive, how often they need to go to the hospital for non-accidental reasons, and whether providing the vaccine daily is a cost-effective solution.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • All children registered during pregnancy in Oio, Biombo or Farim by CHWs or the BHP HDSS
- Exclusion Criteria:
- • Children, who have died within 1 day after birth
- • Children born outside Oio, Biombo and Farim health regions
About Bandim Health Project
The Bandim Health Project is a leading research initiative based in Guinea-Bissau, dedicated to improving public health outcomes through rigorous scientific investigation. Established in collaboration with local health authorities and international partners, the project focuses on a wide range of health issues, including disease prevention, maternal and child health, and infectious diseases. With a commitment to evidence-based practices, the Bandim Health Project conducts clinical trials and observational studies to inform healthcare policies and interventions, ultimately aiming to enhance health services and promote well-being in the region. Through its innovative research and community engagement, the project plays a crucial role in advancing global health knowledge and practices.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bissau, , Guinea Bissau
Patients applied
Trial Officials
Ane B Fisker, MD, PhD
Principal Investigator
Bandim Health Project and University of Southern Denmark
Andreas M Jensen, MSc
Principal Investigator
Bandim Health Project and University of Southern Denmark
Julie O Vedel, MD
Principal Investigator
Bandim Health Project and University of Southern Denmark
Sanne M Thysen, MD, PhD
Study Director
Bandim Health Project and Center for Clinical Research and Prevention, Hospital of Bispebjerg and Frederiksberg
Christine S Benn, MD,PhD,DMSc
Study Director
Bandim Health Project and University of Southern Denmark
Peter Aaby, DMSc
Study Director
Bandim Health Project
Aksel Jensen, MSc, PhD
Study Director
Department of Public Health, University of Copenhagen
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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