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Can BCG Vaccination at First Health-facility Contact Reduce Early Infant Mortality?

Launched by BANDIM HEALTH PROJECT · Dec 1, 2020

Trial Information

Current as of July 22, 2025

Recruiting

Keywords

Non Specific Effects Of Vaccines

ClinConnect Summary

This clinical trial is exploring whether giving the BCG vaccine, which helps protect against tuberculosis, more frequently at health facilities can reduce early infant deaths in Guinea-Bissau. Currently, BCG vaccination often happens only once a week if there are enough children present, which can lead to delays. The researchers believe that by making the vaccine available every day, even for just one baby, they can lower the risk of babies dying from non-accidental causes by 25%.

To participate in this study, babies born in three specific regions of Guinea-Bissau (Oio, Biombo, and Farim) and registered by health workers will be eligible, as long as they are not born outside these areas or die within the first day. If their mothers agree, the babies will be monitored until they are 42 days old, which is when they are scheduled for other vaccinations. The study will look at how many babies survive, how often they need to go to the hospital for non-accidental reasons, and whether providing the vaccine daily is a cost-effective solution.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All children registered during pregnancy in Oio, Biombo or Farim by CHWs or the BHP HDSS
  • Exclusion Criteria:
  • Children, who have died within 1 day after birth
  • Children born outside Oio, Biombo and Farim health regions

About Bandim Health Project

The Bandim Health Project is a leading research initiative based in Guinea-Bissau, dedicated to improving public health outcomes through rigorous scientific investigation. Established in collaboration with local health authorities and international partners, the project focuses on a wide range of health issues, including disease prevention, maternal and child health, and infectious diseases. With a commitment to evidence-based practices, the Bandim Health Project conducts clinical trials and observational studies to inform healthcare policies and interventions, ultimately aiming to enhance health services and promote well-being in the region. Through its innovative research and community engagement, the project plays a crucial role in advancing global health knowledge and practices.

Locations

Bissau, , Guinea Bissau

Patients applied

0 patients applied

Trial Officials

Ane B Fisker, MD, PhD

Principal Investigator

Bandim Health Project and University of Southern Denmark

Andreas M Jensen, MSc

Principal Investigator

Bandim Health Project and University of Southern Denmark

Julie O Vedel, MD

Principal Investigator

Bandim Health Project and University of Southern Denmark

Sanne M Thysen, MD, PhD

Study Director

Bandim Health Project and Center for Clinical Research and Prevention, Hospital of Bispebjerg and Frederiksberg

Christine S Benn, MD,PhD,DMSc

Study Director

Bandim Health Project and University of Southern Denmark

Peter Aaby, DMSc

Study Director

Bandim Health Project

Aksel Jensen, MSc, PhD

Study Director

Department of Public Health, University of Copenhagen

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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