Improving Care for Children With Congenital Heart Disease.

Launched by LUND UNIVERSITY HOSPITAL · Dec 11, 2020

Keywords

ClinConnect Summary

Analysing circulating cardiovascular biomarkers using blood samples should improve identification of congenital heart disease in newborns, in particular for those needing future cardiac interventions.

Comparing such biomarker profiles and non-invasive cardiac imaging results over time in infants and children should lead to better understanding of the complex cardiovascular remodelling processes in common congenital heart lesions, such as atrial or ventricular septal defects. This in turn should lead to an improved risk factor assessment model to guide treatment decisions in children with c...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • obtained written informed consent prior to enrolment
• • resident within participating healthcare regions in Sweden during study
• • age 0-17 years at enrolment
• • Controls: No evidence of congenital heart disease and no history of cardiovascular disease
• • Cases: congenital heart lesions prior to open heart surgery or cardiac catheter intervention with grouping into i.e. ventricular septal defects and atrial septal defects, complex and critical cases requiring infant surgery or patency of the arterial duct to maintain the circulation postnatally.
• Exclusion Criteria:
• • inability to obtain written informed consent prior to study enrolment and/or comply with study protocol
• • non-resident in participating healthcare regions of Sweden during study
• • age more than 17 years at enrolment
• • presence of congenital heart disease where the lesion has already been treated by open heart surgery or cardiac catheter intervention
• • participation in other research study with conflicting aims / interests