Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies

Launched by UNIVERSITY OF GENEVA, SWITZERLAND · Dec 9, 2020

Keywords

ClinConnect Summary

This clinical trial is studying the use of antibiotics to help treat severe periodontal disease, which is an infection that affects the gums and can lead to tooth loss. Traditional treatment mainly involves cleaning the teeth to remove harmful bacteria, but sometimes this isn't enough. The researchers want to find the best way to use antibiotics alongside these cleaning procedures to eliminate certain bacteria more effectively. They will look at how the body processes these medications over different treatment lengths—either 3 days or 7 days—to ensure that patients receive the right amount without causing other health issues.

To participate in this study, individuals need to be between 18 and 80 years old and require periodontal treatment that includes antibiotics. They should have significant gum issues, like pockets deeper than 6mm, and at least 30% of their teeth affected. However, certain people cannot join, such as those with serious health conditions, pregnant or breastfeeding women, and anyone who has recently taken antibiotics. Participants can expect to attend regular check-ups and will help researchers gather important information about how antibiotics work in treating their gum disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Informed Consent as documented by signature
• • Aged 18-80 years old with need of periodontal treatment associated with adjunctive antibiotic therapy
• • Presence of at least 30% of the teeth in the mouth with PD\>6mm and BOP
• Exclusion Criteria:
• • Persons with systemic illnesses (uncontrolled diabetes mellitus, cancer, human immunodeficiency virus, bone metabolic diseases or disorders that compromise wound healing, radiation, or immunosuppressive therapy)
• • Pregnancy or lactation
• • Persons who had taken AB within the previous 2 months
• • Persons who are taking nonsteroidal anti-inflammatory drugs
• • Persons who have a confirmed or suspected intolerance to 5-nitroimidazole derivatives or amoxicillin or macrolides
• • Previous periodontal therapy the last 1 year
• • Known or suspected non-compliance, drug or alcohol abuse
• • Inability to follow due to language problems, psychological disorders, dementia, etc. of the participant
• • Participants not willing to attend regular dental maintenance visits and follow-up evaluations
• • Participation in another study with investigational drug within the 30 days preceding and during the present study