Mediterranean Diet Post-liver Transplantation

Launched by MAYO CLINIC · Dec 14, 2020

Keywords

ClinConnect Summary

This clinical trial is looking at how a Mediterranean diet can help patients after they have had a liver transplant. The Mediterranean diet is rich in fruits, vegetables, whole grains, and healthy fats, and the study aims to see if following this diet can help prevent weight gain, promote heart health, and reduce the risk of fatty liver disease in these patients.

To be eligible for this study, participants need to be adults aged 18 or older who are about to undergo their first liver transplant and have a body mass index (BMI) of 25 or higher. However, individuals with certain health issues, like uncontrolled diabetes or active eating disorders, cannot participate. Those who join the study can expect to follow a structured eating plan based on Mediterranean foods and will be monitored for how this diet affects their health after the transplant. This trial is important because it could provide valuable insights into how diet can play a role in recovery and long-term health after liver transplantation.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Adult patients ≥ 18 years of age undergoing primary liver transplant
• • Ascites-adjusted BMI ≥ 25 kg/m2
• • Acceptable graft function (total bilirubin level \< 5 mg/dL and doppler ultrasound with patent hepatic artery, hepatic veins and portal veins)
• • Exclusion Criteria
• • Hepatocellular carcinoma (HCC) that did not fulfill Milan criteria as per explant histology
• • Untreated post-transplant vascular complications or biliary strictures
• • Multi-organ transplantation
• • Urine protein excretion ≥2.0 g/day
• • Uncontrolled diabetes mellitus (HbA1c \> 10%)
• • Associated medical conditions incompatible with safe participation in a nutritional intervention study, including digestive diseases with fat intolerance, neurological, psychiatric or endocrine disorders
• • Active eating disorder (e.g. bulimia nervosa, anorexia nervosa)
• • History of bariatric surgery
• • Pregnancy or planning on pregnancy in the next year