iCorMicA - Stratified Medicine in Angina

Launched by NHS GREATER GLASGOW AND CLYDE · Dec 17, 2020

Keywords

ClinConnect Summary

The iCorMicA study is looking at how different treatment plans can help people with angina, a type of chest pain, especially those who have symptoms but do not have blocked arteries. The goal is to see if a personalized treatment approach, guided by a special diagnostic procedure during a heart test called coronary angiography, can improve symptoms, overall well-being, and heart health in these patients. This trial is currently recruiting participants aged 18 and older who are scheduled for this heart test and have angina symptoms.

To join the study, participants must not have a history of major heart surgery or serious blockages in their coronary arteries. Those who take part can expect to receive either the personalized treatment or a placebo (a "dummy" treatment) without knowing which one they are getting, as the trial is designed to be fair and unbiased. This means everyone will have an equal chance of receiving the actual treatment or the placebo. The study aims to provide important insights into how to better manage angina symptoms for many people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years.
• • 2. A clinical plan for invasive coronary angiography.
• • 3. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
• • 4. Able to comply with study procedures.
• • 5. Able to provide informed consent.
• Exclusion Criteria:
• • 1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
• • 2. History of coronary artery bypass surgery.
• • 3. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*.
• • 4. Logistical reason\*. \*These patients will enter a follow-up registry.