A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Dec 16, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a new way to monitor and treat patients who have a condition called familial adenomatous polyposis (FAP), which causes many polyps (growths) in the stomach and intestines. The goal of the study is to see if a personalized plan for regular check-ups and treatments can help manage these polyps safely and effectively. The trial is currently looking for participants aged 18 and older who have been diagnosed with FAP, either through genetic testing or by having a large number of polyps along with a family history of the condition.

If you join this trial, you will receive tailored care designed to keep track of your polyps and address any concerns that arise. However, there are some important criteria for participation. For example, you cannot participate if you have already had all your polyps removed or if you have stomach or intestinal cancer at the start of the study. This trial aims to improve how we support people with FAP, helping them manage their health more effectively.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
• • Age 18 years or older
• Exclusion Criteria:
• • Endoscopic removal of all polyps with an indication for removal not possible/feasible
• • Gastric or duodenal cancer at baseline endoscopy
• • Need for surgery