A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Dec 16, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a personalized plan to monitor and help patients with Familial Adenomatous Polyposis (FAP) who have already had surgery to remove their colon and rectum. FAP is a genetic condition that can lead to many polyps, or growths, in the intestines, which can become cancerous if not managed. The goal of the trial is to see how effective and safe this personalized approach is for these patients.

To be eligible for the study, participants must be at least 18 years old and have a confirmed diagnosis of FAP, either through genetic testing or a history of many polyps along with a family history of the condition. They should also have had surgery to remove their colon and rectum. If you join the trial, you can expect to be monitored closely and receive tailored interventions based on your needs. This can help improve your health outcomes and quality of life after surgery. The trial is currently recruiting participants, and anyone interested should reach out to the study team for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
• • Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA
• • Age 18 years or older
• Exclusion Criteria:
• • Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies
• • Cancer at baseline endoscopy
• • Need for surgery