Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.

Launched by INSTITUTE OF HEMATOLOGY & BLOOD DISEASES HOSPITAL, CHINA · Dec 25, 2020

Keywords

ClinConnect Summary

This clinical trial is looking at whether a medication called chlorpheniramine can help prevent allergic reactions that some people experience after receiving blood transfusions. The study is comparing chlorpheniramine to a placebo, which is an inactive substance that looks like the real medication but has no effect. It aims to find out if chlorpheniramine can reduce the chances of these allergic reactions during blood transfusions.

To participate, individuals need to be between 18 and 65 years old and have a blood disorder that requires them to receive blood products, such as red blood cells or platelets. However, people with a history of allergies, recent use of certain allergy medications, or specific health conditions may not be eligible. If you join this trial, you can expect to receive either the chlorpheniramine or the placebo before your transfusion, and neither you nor the medical team will know which one you received. This helps ensure the results are fair and unbiased. If you're interested in participating or want to learn more, it's a good idea to talk to your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18\~65 years old.
• • Subject is diagnosed with hematological disorder and requires blood product (i.e. suspended red blood cells, apheresis platelets, fresh frozen plasma) transfusions.
• • Subject can fully understand and voluntarily sign informed consent forms.
• Exclusion Criteria:
• • Subject with a history of allergic diseases.
• • Subject experienced at least 1 moderate/severe or 2 mild allergic reactions in the past.
• • Subject received glucocorticoid or allergy drugs within 24 hours before blood transfusion.
• • Subject transfused with washed RBC.
• • Received allo-HSCT transplantation before.
• • Subject with heart failure.
• • Subject suffered from sequelae of cardiovascular or cerebrovascular diseases.
• • Pregnant or nursing women.
• • Inability to understand or to follow study procedures.