Stellate Ganglion Block and Cerebral Vasospasm

Launched by BEIJING TIANTAN HOSPITAL · Dec 29, 2020

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called Stellate Ganglion Block (SGB) to see if it can help prevent or improve cerebral vasospasm (cVS) in patients who have had a subarachnoid hemorrhage (SAH) caused by an aneurysm. Cerebral vasospasm is a condition where blood vessels in the brain narrow, which can lead to serious problems like delayed brain damage. The trial aims to find out if giving SGB shortly after the bleeding can help open up these blood vessels and reduce the risk of complications.

To participate in this trial, individuals must be between 18 and 65 years old and must have experienced an aneurysmal subarachnoid hemorrhage within the last 48 hours, with plans for surgical treatment. They also need to be in a specific condition before surgery. Those who have certain types of aneurysms, severe bleeding disorders, or other specific medical issues may not be eligible. Participants will receive the SGB treatment and will be monitored to see how it affects their condition. It's an important study that hopes to improve outcomes for patients facing this serious health challenge.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age range: 18-65 years old;
• • Within 48 hours after onset of aSAH,and planning surgical treatment(aneurysm clipping);
• • Preoperative Hunt-Hess grade 2-3
• • Sign informed consent.
• Exclusion Criteria:
• • ASA \> grade III;
• • Patients with posterior circulation aneurysm, ophthalmic aneurysms or internal carotid aneurysms;
• • patients with multiple aneurysms;
• • Patients with severe coagulation dysfunction;
• • Patients with trauma and local infection in the nerve block area;
• • Local anatomic structure changes (neck structure changes caused by radiotherapy, chemotherapy and surgery);
• • MCA stenosis or infarction was found by preoperative imaging;
• • Patients with poor temporal window signal revealed by preoperative TCD (clear waveform image could not be obtained);
• • Allergy to known local anesthetics;
• • Pregnant and lactating women.