Effect of Intermittent Hypoxia in Healthy Individuals

Launched by SHIRLEY RYAN ABILITYLAB · Dec 28, 2020

Keywords

ClinConnect Summary

The use of acute intermittent hypoxia (AIH), has been demonstrated, through human and animal studies, to be an effective way of increasing spinal motor excitability and strengthening residual synaptic connectivity. AIH utilizes short duration (\<2 min) exposures to reduced oxygen levels (\~10% inspired oxygen), with alternating exposures to air with normal oxygen levels (\~21% inspired oxygen).

Previous publications demonstrate that AIH is a safe and effective intervention to modify motor function in individual with chronic incomplete spinal cord injuries. The use of AIH has been shown to ...

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Eligibility criteria

• Inclusion Criteria:
• • No history of neurologic injury or progressive neuromuscular disorder
• • Individuals ages 18-70 years old
• • Must be medically stable with no history of cardiovascular instability, congestive heart failure or stroke
• • Not currently (\>2 weeks) on any medications related to spasticity
• • No history of Sleep apnea
• • Not a current smoker
• • Able to comply with protocol/study requirements
• Exclusion Criteria:
• • Recent change in the use of narcotic, anti-inflammatory or pain medication
• • unstable medical conditions or any other clinical observation that may affect the candidate's performance, health, safety or the ability to participate in the study determined by the treating therapist or coordinating staff
• • Active participation in another movement research study or therapy program
• • Anti-spasticity drug injection less than 3 months prior to beginning treatment
• • Musculoskeletal pain that interferes with participation in study
• • Women who are currently, may be, or planning on becoming pregnant
• * for fMRI participation, participants will be excluded if they have:
• • Metal fragments in eyes or face
• • Implantation of any electronic devices such as (but not limited to) cardiac pacemakers, cardiac defibrillators, cochlea implants, or nerve stimulators
• • Vascular surgery
• • Claustrophobia
• • Body piercing or tattoos