Early Diagnosis of SCD Based on Radiogenomics

Launched by XUANWUH 2 · Jan 3, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how to better identify early signs of Alzheimer's disease (AD) in people who notice subtle changes in their thinking and memory, a condition known as subjective cognitive decline (SCD). The researchers aim to compare information from participants in Germany and China, looking at brain scans, genetic data, and other health markers to create a more accurate way to diagnose preclinical Alzheimer's, which means changes in the brain that occur before more noticeable symptoms develop.

To be eligible for this study, participants need to be between 60 and 79 years old, speak Mandarin, and notice a gradual decline in their thinking abilities compared to their earlier selves. Importantly, they should not have any other major health issues that could affect their memory, such as a history of stroke or depression. If you decide to participate, you can expect to undergo various tests and assessments, including cognitive tests and brain imaging, which will help researchers understand how SCD relates to Alzheimer's. This study is currently recruiting participants and aims to improve how we diagnose and understand Alzheimer's disease for different populations.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 60-79 years old, right-handed and Mandarin-speaking subjects;
• • self-experienced persistent decline in cognitive capacity in comparison with a previously normal status and unrelated to an acute event;
• • normal age-, gender- and education-adjusted performance on standardised cognitive tests;
• • concerns (worries) associated with memory complaint;
• • failure to meet the criteria for MCI or dementia
• Exclusion Criteria:
• • a history of stroke;
• • major depression (Hamilton Depression Rating Scale score \> 24 points);
• • other central nervous system diseases that may cause cognitive impairment, such as Parkinson's disease, tumors, encephalitis and epilepsy;
• • cognitive impairment caused by traumatic brain injury;
• • systemic diseases, such as thyroid dysfunction, syphilis and HIV;
• • a history of psychosis or congenital mental growth retardation