Effects of a Multispecies Probiotic on Migraine

Launched by SCRIPPS HEALTH · Jan 4, 2021

Keywords

ClinConnect Summary

Given the significant unmet need for improved therapies that address migraine disorders and concurrent irritable bowel syndrome (IBS), this study seeks to investigate the impact of probiotics on the sequelae of symptoms associated with both migraine and IBS.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Episodic migraine diagnosis for a minimum of 1 year (12-months)
• • Between 3-12 migraine episodes /month
• • Comorbid, symptomatic, irritable bowel syndrome during the screening period
• • On a steady treatment regimen: preventative and acute migraine medications and therapies unchanged over the last 6 months
• • Access to Scripps Center for Integrative Medicine
• • Access to smartphone or computer to complete electronic surveys
• Exclusion Criteria:
• • Other GI or hepatic diagnoses (Inflammatory Bowel Disease (IBD), Small Intestinal Bacterial Overgrowth (SIBO), Non-Alcoholic Fatty Liver Disease (NAFLD), elevated Liver Function Tests (LFTs) within the last 6 months)
• • Prior GI surgery
• • Prior GI infection in the previous 3-months
• • Antibiotic treatment in previous last 3 months
• • Diagnosed Autoimmune disease
• • Current corticosteroids use
• • Morbid obesity (BMI \>40)
• • Took Probiotics or Probiotic-containing supplements or therapy in the previous 3-months
• • Diagnosis of post-traumatic headache or cervicogenic headache
• • Pregnancy or plans to become pregnant during study participation