Genetic Variants and Regulation of Specialized Pro-resolving Mediator

Launched by QUEEN MARY UNIVERSITY OF LONDON · Jan 5, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how certain genetic variations might affect the body's ability to control inflammation. Inflammation is a natural response to injury or infection, but when it becomes uncontrolled, it can lead to serious health issues like rheumatoid arthritis and heart disease. The researchers are particularly interested in understanding how specific genes related to important molecules called specialized pro-resolving mediators (SPM) influence inflammation and disease progression. By examining these genetic factors, the study hopes to uncover new insights that could lead to better treatments for inflammatory diseases.

To participate in this study, you need to be a current volunteer in the Genes & Health program, which is a long-term research project focusing on individuals of Bangladeshi and Pakistani descent. Eligible participants should have had their genes sequenced as part of this program. The researchers are looking for people aged 65 to 74, regardless of whether they have specific genetic mutations. If you join the study, you can expect to contribute to important research that could improve our understanding of inflammation and develop better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Current volunteer of the Genes \& Health program with (test) or without (control) relevant genetic mutations. Genes \& Health is a huge long-term study of 100,000 people of Bangladeshi and Pakistani origin focuses to link genes with health records and to study disease and treatments. When a volunteer participates in this program, they agree to the possibility to be invited for further studies. Gene \& Health program invites volunteers to take part in two regions of the UK: East London and Bradford.
• Exclusion Criteria:
• • 1. Volunteer that has not had their genome sequenced after taking part in Stage 1 of Genes \& Health program.
• • 2. Volunteer with significant genetically inherited conditions.
• • 3. Any abnormality or pre-existing disease which, in the opinion of the investigator, might either expose the subject to risk, or influence the validity of the results.
• • 4. Volunteer that went under surgery and are recovering.
• • 5. Participation in a clinical study of a new chemical entity, biological product or a prescription medicine, or loss of more than 400 mL blood, within the previous 3 months.
• • 6. Presence or history of drug or alcohol abuse.