The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Study

Launched by UNC LINEBERGER COMPREHENSIVE CANCER CENTER · Jan 6, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a supplement called SCFA (short-chain fatty acids) on people receiving radiation therapy for certain types of cancer in the abdomen or pelvis. The goal is to see if SCFA can help reduce gastrointestinal (GI) side effects caused by radiation, which can be uncomfortable or harmful. Participants will be randomly assigned to receive either the SCFA supplement or a placebo (a sugar pill with no active ingredients) to compare the GI side effects between the two groups.

To be eligible for this trial, individuals must be at least 18 years old and have been diagnosed with a specific type of cancer in the GI, urologic, or gynecologic area that requires radiation treatment. They should be in generally good health, meaning their doctor believes they can safely participate. Participants will need to give consent for the study and may have had prior treatments like chemotherapy or surgery, but they must have recovered from those treatments. Throughout the study, participants will be monitored closely to assess any side effects and their overall health. If you or a loved one are interested in understanding more about this trial or considering participation, please reach out to the study team for more information.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Written informed consent obtained to participate in the study and HIPAA authorization for release of personal health information. Consent for the use of any residual material from biopsy and/or surgical resection (archival tissue) and serial blood draws will be required for enrollment.
• • ≥ 18 years of age on day of signing informed consent.
• • ECOG performance score ≤ 2
• • Subjects with histological or cytological evidence/confirmation of GI, urologic or gynecologic malignancy that will be treated with minimum dose of 40Gy (equivalent dose in 2Gy per fraction or EQD2) via 3D conformal fields or IMRT to abdomen or pelvis (multimodality treatment with surgery, chemotherapy is permissible)
• • Subjects may have had prior chemotherapy or surgery.
• • Subjects deemed healthy for study inclusion by the treating physician based on the laboratory values at screening and general health status.
• • Prior cancer treatment must be completed at least 14 days prior to registration and the subject must have recovered from all reversible acute toxic effects of the regimen (other than alopecia) to ≤ Grade 1 or baseline.
• • Females of childbearing potential must have a negative urine pregnancy test within 14 days prior to simulation. NOTE: Females are considered of childbearing potential unless they are surgically sterile (have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are naturally postmenopausal for at least 12 consecutive months. Documentation of postmenopausal status must be provided.
• • Females of childbearing potential must be willing to abstain from heterosexual activity or to use 2 forms of effective methods of contraception from the time of informed consent until 14 or 28 days after treatment discontinuation. The two contraception methods can be comprised of two barrier methods, or a barrier method plus a hormonal method or an intrauterine device that meets \< 1% failure rate for protection from pregnancy in the product label.
• • Male subjects with female partners of childbearing potential must have had a prior vasectomy or agree to use an adequate method of contraception (i.e., double barrier method: condom plus spermicidal agent) starting with the first dose of study therapy through 14-28 days after the last dose of study therapy.
• • Subjects is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.
• Exclusion Criteria:
• • Pregnant or breastfeeding (NOTE: breast milk cannot be stored for future use while the mother is being treated on study).
• • Prior abdominopelvic RT
• • History of inflammatory bowel disease or GI motility disorder
• • Grade 2 or higher diarrhea at baseline unless deemed by the investigator to be caused by laxatives prescribed for symptomatic partial obstruction
• • Concurrent use of histone deacetylase inhibitors (vorinostat)
• • Baseline hypernatremia defined as serum sodium concentration \>145 mEg/L
• • Creatinine clearance \< 50 mL/min
• • Congestive heart failure
• • On a salt restricted diet for medical indications
• • Severe nut allergy
• • Active infection requiring systemic therapy.
• • Active central nervous system (CNS) metastases
• • Treatment with any investigational drug other than the drugs in this study and subjects may not be on another clinical trial.
• • Subject is receiving prohibited medications or treatments as listed in section 5.6 of the protocol that cannot be discontinued/replaced by an alternative therapy.