Immuno-inflammatory Profile and Response to Ischemic Stroke Reperfusion Therapies (IMMUNOSTROKE)

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · Jan 7, 2021

Keywords

ClinConnect Summary

The IMMUNOSTROKE study is looking at how the immune system and inflammation affect patients who have suffered an ischemic stroke, which is a type of stroke caused by a blockage in the blood vessels of the brain. The goal is to understand how these factors change during treatment that aims to restore blood flow, and how they relate to recovery in terms of physical and thinking abilities after the stroke.

To participate in this trial, individuals must be experiencing an ischemic stroke and be eligible for specific treatments that help restore blood flow, such as medications or procedures. However, certain conditions may prevent someone from joining, including having a brain bleed, severe prior neurological issues, or specific medical devices that can interfere with imaging tests. This study is not yet recruiting participants, but it aims to provide valuable insights that could improve stroke treatment and recovery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Presenting an ISCHEMIC STROKE for which reperfusion treatment is indicated according to European and North American recommendations (intraveinous thrombolysis or mechanical thrombectomy or a combination of both)
• Exclusion Criteria:
• • Contraindication to performing a cerebral MRI (claustrophobia, pacemaker or other implantable device contraindicating the performance of MRI)
• • Intracranial haemorrhage associated with AIC on initial imaging
• • Immunosuppressive treatment or corticosteroid therapy on admission of the patient
• • Pre-existing neurological disability limiting the neurological assessment to 3 months (mRS\>2 on admission)
• • Dementia known and diagnosed pre-existing at ischemic stroke
• • Absolute or relative contraindication to gadolinium injection (history of true allergic reaction or intolerance to gadobutrol, renal failure with creatinine clearance \<15mL/min, pregnant or breastfeeding woman).