Functional Lung Imaging With DECT and 4DCT

Launched by ABRAMSON CANCER CENTER AT PENN MEDICINE · Jan 7, 2021

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technique called 4DCT (four-dimensional computed tomography) to help doctors better understand how non-small cell lung cancer behaves in patients. The trial aims to enroll 40 patients who have advanced stages (Stage III or IV) of this type of lung cancer and are planning to receive treatment that combines chemotherapy and radiation therapy. This study will help researchers learn if this advanced imaging can provide useful information for treatment planning.

To be eligible for the trial, patients must be at least 18 years old and diagnosed with non-small cell lung cancer that is either Stage II, III, or IV. They should not have any other planned lung radiation treatments until after the second CT scan in the study. Patients will also need to have good kidney function and will be required to take a pregnancy test if they are female. Participants can expect to undergo a special type of CT scan with a contrast dye, which helps create clearer images of the lungs. This trial is currently recruiting participants, and it's a great opportunity to contribute to important research that could improve cancer care in the future.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Patients have histologic diagnosis of non-small cell lung cancer
• • Patients have AJCC stage II, III or IV disease were the plan is to receive definitive concurrent chemoradiation to 60 Gy or higher
• • Age \> 18 years of age
• • Patients are able to provide informed consent
• • No additional lung radiation is planned until after the 2nd CT on this study (i.e. patient does not have a solitary pulmonary nodule or second primary that the plan is to undergo SBRT)
• • Patient must have adequate kidney function to receive IV contrast (following institutional policy supplied by radiology). The cutoff level for serum creatinine is 1.6 mg/dL
• • Negative urine pregnancy test before every CT scan
• Exclusion criteria:
• • Allergy to IV iodine contrast
• • Severe claustrophobia
• • Further thoracic radiation therapy is planned.