Establishment of Genomic, Transcriptomic and Functional Characteristics of Tumor Cells in Hyperinflammatory Hemopathies

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Jan 8, 2021

Keywords

ClinConnect Summary

This clinical trial is studying certain blood disorders known as monoclonal gammopathies, which include conditions like Multiple Myeloma and Waldenstrom Macroglobulinemia. Some patients with these conditions can experience unexplained inflammation and symptoms such as fevers, rashes, or joint pain. The researchers want to understand if there are specific genetic changes in tumor cells that might be causing these inflammatory symptoms. They are looking to identify the inflammatory pathways that could be activated in these patients.

To participate, individuals must be at least 18 years old and able to provide informed consent. They should be receiving care for one of the targeted conditions and have a fever along with other specific symptoms like a rash or joint pain. It's important to note that the trial is not yet recruiting participants, and only those who can communicate effectively and understand the study will be eligible. If someone qualifies, they can expect to undergo tests that will help researchers learn more about these conditions and their effects on inflammation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient over 18 years of age with the capacity to give express free and informed consent.
• • Patient followed in one of the services participating in the study and meeting the 2 following conditions
• • 1. have myelodysplastic syndrome, or multiple myeloma, or monoclonal gammopathy of undetermined significance, or Schnitzler's syndrome.
• • 2. have a fever of undetermined etiology associated with one of the following symptoms: rash, arthralgia or arthritis, serositis, abdominal pain.
• Exclusion Criteria:
• • Patient incapable of giving express free and informed consent.
• • Subject under guardianship, curatorship or safeguarding of justice.
• • Subject does not speak French.
• • Subject incapable of answering questions or expressing himself/herself.
• • Presence of a differential diagnosis that may explain the patient's symptoms.