Pregabalin vs. Gabapentin on Reducing Opioid Usage

Launched by CAMC HEALTH SYSTEM · Jan 8, 2021

Keywords

ClinConnect Summary

This clinical trial is exploring how well two medications, Pregabalin and Gabapentin, work alongside traditional opioid pain medications to help reduce the amount of opioids needed for patients recovering from orthopedic trauma, which involves injuries to bones and joints. The aim is to see if these medications can help manage pain effectively while allowing patients to use fewer opioids, which can help prevent potential issues related to opioid use.

To participate in this trial, you need to be at least 18 years old and have been admitted to the hospital for treatment of an orthopedic injury. You should also have an active prescription for opioids when you join the study. If you meet these criteria, you may be included in the research. If you enroll, you can expect to receive either Pregabalin or Gabapentin in addition to your usual pain medication during your hospital stay. This study is currently recruiting participants, and it’s important to note that some patients may not be eligible based on certain medical conditions or treatments they are receiving.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Nurse Practitioner service admissions
• • 2. 18 years of age or older
• • 3. Patients enrolled within 36 hours of admission
• • 4. Anticipated duration of hospitalization \> 24 hours from time of consent
• • 5. Active order(s) for opioids in place at the time of enrollment
• Exclusion Criteria:
• • 1. Clinician discretion based on patient care management
• • 2. Intubated patients
• • 3. Patients with epidural
• • 4. Patients with pregabalin/gabapentin as home medications
• • 5. Patients receiving pregabalin/gabapentin upon admission
• • 6. Traumatic brain injury patients
• • 7. CrCl\<30ml/min or on HD
• • 8. Unable to take enteral medications
• • 9. On Patient Controlled Analgesia (PCA)
• • 10. Patients with complicated wound closure
• • 11. History of epilepsy
• • 12. Documented history of substance use disorder