18F-DOPA II - PET Imaging Optimization

Launched by UNIVERSITY OF ALBERTA · Jan 11, 2021

Keywords

ClinConnect Summary

The 18F-DOPA II clinical trial is studying a type of imaging called PET/CT to see how it can be improved for diagnosing certain health conditions. This trial focuses on patients who are either children or adults with specific diseases, including congenital hyperinsulinism (a condition that causes high insulin levels), neuroblastoma (a type of cancer), neuroendocrine tumors, Parkinson's disease, Lewy body dementia, and brain tumors. The goal is to enhance the quality of the images produced during the scans and to examine how the gallbladder works during these procedures.

To participate in this trial, patients must meet certain criteria. For example, children under 18 with congenital hyperinsulinism or neuroblastoma can join, as well as adults suspected of having Parkinson's disease or neuroendocrine tumors. Participants will undergo PET/CT scans, which typically last about 20-30 minutes, and they will need to lie flat during the process. It's important to know that not everyone can participate; for instance, individuals who are pregnant or have certain weight restrictions will be excluded. Overall, this study aims to improve the effectiveness of PET imaging, which could lead to better diagnosis and treatment for these conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Pediatric patients (less than 18 years old) with congenital hyperinsulinism.
• • 2. Pediatric patients (less than 18 years old) with neuroblastoma.
• • 3. Pediatric (less than 18 years old) or Adult patients (18 or older) with known or clinically suspected neuroendocrine tumor.
• • 4. Adult patients (18 or older) with a clinical suspicion of Parkinson's disease or Lewy body dementia.
• • 5. Pediatric (less than 18 years old) or Adult patients (18 or older) with brain tumors.
• Exclusion Criteria:
• • 1. Unable to obtain consent
• • 2. Weight \>225 kg (weight limitation of PET/CT scanner)
• • 3. Adult patients unable to lie flat for 20-30 minutes to complete the PET-CT session.
• • 4. Young pediatric patients (less than 13 years old) who are unable to lie flat for 20-30 minutes and for whom clinical sedation is contraindicated (as determined by a pediatric anaesthesiologist).
• • 5. Lack of intravenous access
• • 6. History of previous cholecystectomy (excluded from dynamic abdomen sub-study only)
• • 7. Pregnancy